Document Detail


Microcapsule chemoembolization for head and neck cancer.
MedLine Citation:
PMID:  4041174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cisplatin (CDDP) was microencapsulated with ethylcellulose, and microcapsules (CDDP-mc) were infused into the maxillary arteries of patients with various head and neck carcinomas. We then found that the CDDP level in the circulating blood was significantly lower than that in patients administrated intravenous non-excapsulated CDDP. However, significantly high concentrations of CDDP were found in the tissues of patients treated with CDDP-mc. Our results suggest that selective arterial infusions of CDDP-mc can exert an intensive topical antitumor effect through microinfarction of malignant tissues. The prolonged release of drug from the microcapsules has also been associated with minimal systemic side effects.
Authors:
Y Okamoto; A Konno; K Togawa; T Kato; Y Amano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of oto-rhino-laryngology     Volume:  242     ISSN:  0302-9530     ISO Abbreviation:  Arch Otorhinolaryngol     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-10     Completed Date:  1985-10-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0414105     Medline TA:  Arch Otorhinolaryngol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  105-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma, Squamous Cell / drug therapy*
Cisplatin / administration & dosage,  blood,  therapeutic use*
Combined Modality Therapy
Embolization, Therapeutic / methods*
Female
Humans
Infusions, Intra-Arterial
Male
Maxillary Sinus Neoplasms / drug therapy*
Middle Aged
Mouth Neoplasms / drug therapy*
Nose Neoplasms / drug therapy*
Paranasal Sinus Neoplasms / drug therapy*
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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