Document Detail


Microcalorimetry studies on the antibacterial effect of crude monkshood polysaccharide.
MedLine Citation:
PMID:  21726063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this paper, crude monkshood polysaccharide was isolated from Radix Aconiti Lateralis Preparata. The effects of crude monkshood polysaccharide on Escherichia coli and Staphylococcus aureus were investigated by microcalorimetry. The power-time curves of the bacterial growth at various concentrations (c) of crude monkshood polysaccharide were plotted with a TAM air isothermal microcalorimeter at 37 °C. The growth rate constant (μ), inhibitory ratio (I), peak-height (P(m)), and peak-time (t(m)) were calculated. From the data, the relationship between μ and c also was established. The growth rate constant μ decreased with the increasing concentrations of crude monkshood polysaccharide. Moreover, P(m) reduced and t(m) increased with increasing concentrations. The experimental results revealed that crude monkshood polysaccharide had inhibitory activity towards S. aureus and E. coli. Results obtained from our study strongly suggest that microcalorimetry is a fast, simple, and more sensitive technology that can be easily performed to study the effect of drugs on bacteria.
Authors:
Gui-mei Lin; Lian Liu; Wei Shao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  12     ISSN:  1862-1783     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-04     Completed Date:  2011-10-31     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  563-7     Citation Subset:  IM    
Affiliation:
School of Pharmaceutical Science, Shandong University, Jinan 250012, China.
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MeSH Terms
Descriptor/Qualifier:
Aconitum / chemistry*
Anti-Bacterial Agents / pharmacology*
Calorimetry / methods*
Escherichia coli / drug effects
Polysaccharides / pharmacology*
Staphylococcus aureus / drug effects
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Polysaccharides
Comments/Corrections

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