Document Detail

Microcalorimetric study of Escherichia coli growth inhibited by the selenomorpholine complexes.
MedLine Citation:
PMID:  11051606     Owner:  NLM     Status:  MEDLINE    
The inhibitory or antibiotic action of four kinds of the selenomorpholine complex on a strain of Escherichia coli was studied by microcalorimetry. Differences in their capacities to inhibit the metabolism of this bacterium were observed. The extent and duration of the inhibitory effect on the metabolism as judged from the rate constant, k, and the half-inhibitory concentration, IC50, varied with the different drugs. The rate constant (k) of Escherichia coli (in the log phase) in the presence of the drugs decreased with increasing concentrations of the drugs (C). The relationship of k and C is nearly linear for (1) selenomorpholine and (2) selenomorpholine hydrochloride, but for (3) N,N'-methylene bisselenomorpholine and (4) N-dodecyl selenomorpholine, it is not linear. The experimental results reveal that the sequence of antibiotic activity of selenomorpholines is (3) and (4) > (1) > (2).
X Li; Y Liu; R Zhao; J Wu; X Shen; S Qu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  75     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-16     Completed Date:  2000-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-75     Citation Subset:  IM    
Department of Chemistry, Wuhan University, People's Republic of China.
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MeSH Terms
Escherichia coli / drug effects*,  growth & development*
Morpholines / pharmacology*
Selenium Compounds / pharmacology*
Reg. No./Substance:
0/Morpholines; 0/Selenium Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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