Document Detail

Microbubble transport through a bifurcating vessel network with pulsatile flow.
MedLine Citation:
PMID:  21964559     Owner:  NLM     Status:  Publisher    
Motivated by two-phase microfluidics and by the clinical applications of air embolism and a developmental gas embolotherapy technique, experimental and theoretical models of microbubble transport in pulsatile flow are presented. The one-dimensional time-dependent theoretical model is developed from an unsteady Bernoulli equation that has been modified to include viscous and unsteady effects. Results of both experiments and theory show that roll angle (the angle the plane of the bifurcating network makes with the horizontal) is an important contributor to bubble splitting ratio at each bifurcation within the bifurcating network. When compared to corresponding constant flow, pulsatile flow was shown to produce insignificant changes to the overall splitting ratio of the bubble despite the order one Womersley numbers, suggesting that bubble splitting through the vasculature could be modeled adequately with a more modest constant flow model. However, bubble lodging was affected by the flow pulsatility, and the effects of pulsatile flow were evident in the dependence of splitting ratio of bubble length. The ability of bubbles to remain lodged after reaching a steady state in the bifurcations is promising for the effectiveness of gas embolotherapy to occlude blood flow to tumors, and indicates the importance of understanding where lodging will occur in air embolism. The ability to accurately predict the bubble dynamics in unsteady flow within a bifurcating network is demonstrated and suggests the potential for bubbles in microfluidics devices to encode information in both steady and unsteady aspects of their dynamics.
Doug T Valassis; Robert E Dodde; Brijesh Esphuniyani; J Brian Fowlkes; Joseph L Bull
Related Documents :
15632349 - Non-invasive evaluation of bilateral renal regional blood flow and tubular dynamics dur...
1154799 - The disposition and metabolism of i.c.i. 58,834 (viloxazine) in humans.
17725889 - The distribution of fluoxetine in human fluids and tissues.
5338459 - Intrarenal distribution of blood flow in the transplanted dog kidney: effect of denerva...
8083359 - Structural basis for reduced glomerular filtration capacity in nephrotic humans.
474759 - Regional renin release by the cat kidney in vitro and in vivo.
19450519 - Hematopoietic stem cell development is dependent on blood flow.
9309989 - Expiratory flow limitation in stable asthmatic patients during resting breathing.
7507319 - Laminar flow stimulates atp- and shear stress-dependent nitric oxide production in cult...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-1
Journal Detail:
Title:  Biomedical microdevices     Volume:  -     ISSN:  1572-8781     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887374     Medline TA:  Biomed Microdevices     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109-2110, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunctio...
Next Document:  Cationic antimicrobial peptides in clinical development, with special focus on thanatin and heliomic...