Document Detail

Microbubble generation and transmission of medtronic's affinity hardshell venous reservoir and collapsible venous reservoir bag: an in-vitro comparison.
MedLine Citation:
PMID:  22164449     Owner:  NLM     Status:  In-Process    
Microemboli are implicated in neurological injury; therefore, the extracorporeal circuit (ECC) should not generate microbubbles or transmit introduced air. The venous reservoir is the first component in the ECC designed to remove introduced air. The purpose of this study was to investigate the relative safety of two kinds of adult venous reservoirs--the closed soft-shell venous reservoir (SSVR [Medtronic CBMVR 1600]) and the open hard-shell venous reservoir (HSVR [Affinity NT CVR])--in terms of microbubble generation and introduced air transmission. A recirculating in-vitro circuit was used to compare the two reservoirs with the SSVR further assessed in a fully closed or partially open state. Microbubbles were counted using a Hatteland CMD-10 Doppler in the outflow of the reservoirs before (microbubble generation) and after infusing 20 mL/min of air into the venous line (microbubble transmission) while altering pump flow rates (3 L/min; 5 L/min) and reservoir prime (200 mL; 700 mL). Negligible bubble generation was noted in the SSVRs at both flow rates and either reservoir volume. However, microbubble generation was significant in the HSVR at the higher flow rate of 5 L/min and lower reservoir volume of 200 mL. When infusing air, a flow of 3 L/min was associated with insignificant to small increases in microbubble transmission for all reservoirs. Conversely, infusing air while flowing at 5 L/min was associated with significantly more microbubble transmission for all reservoirs at both low and high reservoir volumes.The SSVR is as safe as the HSVR in microbubble handling as the generation and transmission of microbubbles by the SSVR is not more than the HSVR over a range of prime volumes and flow rates. As both reservoirs transmitted microbubbles at higher pump flow rates regardless of reservoir volumes, it is important to eliminate venous air entrainment during cardiopulmonary bypass.
Kieron C Potger; Darryl McMillan; Mark Ambrose
Related Documents :
1861319 - Renal blood flow measurements using radioactive microspheres in a porcine model with un...
195269 - Inhibitory effect of methylxanthines on feedback control of glomerular filtration rate ...
1105839 - Dominant role of complement in the hyperacute xenograft rejection reaction.
25440389 - Modern banking, collection, compatibility testing and storage of blood and blood compon...
24675829 - Accuracy of capillary blood 3-β-hydroxybutyrate determination for the detection and tr...
21963469 - The kinetics of cohesive powder de-agglomeration from three inhaler devices.
7829869 - Flow cytometric analysis of the granulocyte respiratory burst: a comparison study of fl...
17148849 - Evaluation of blood rheology in patients with cyanotic congenital heart disease using a...
1873969 - Multicenter comparison of the high volume (10 ml) nr bactec plus system and the standar...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of extra-corporeal technology     Volume:  43     ISSN:  0022-1058     ISO Abbreviation:  J Extra Corpor Technol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-12-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0267637     Medline TA:  J Extra Corpor Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-22     Citation Subset:  T    
Royal North Shore Hospital, St. Leonards, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  In vitro evaluation of gaseous microemboli handling of cardiopulmonary bypass circuits with and with...
Next Document:  In-vitro quantification of gaseous microemboli in two extracorporeal life support circuits.