| Microbubble contrast agent detection using binary coded pulses. | |
| | |
MedLine Citation:
|
PMID: 17629609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Real-time visualization of microbubbles in the microvasculature of deep tissues remains a challenge for existing nonlinear microbubble imaging techniques. A technique with high sensitivity to nonlinear signals is required to compensate for the effects of limited power used to avoid bubble destruction and the high attenuation of the overlying tissues for deeper targets. The use of coded pulses in ultrasound imaging is well established as a means of improving the signal-to-noise ratio (SNR) within B-mode ultrasound imaging, but the feasibility of this approach for detecting microbubbles has not been well studied. In this work we investigate the use of binary phase encoding together with phase and amplitude modulation (PIAM) for the detection of nonlinear signals from microbubbles. A series of simulation experiments were conducted using a modified Rayleigh-Plesset model together with Golay and Barker coding techniques to investigate (i) the ability of binary encoded PIAM to detect nonlinear signals, (ii) the effect of the SNR and insonating pressure on the detection process, (iii) the sensitivity of different pulse encoding approaches and (iv) the effects of bubble resonance behavior on the detection process. The results show that the binary encoding approach combined with PIAM is able to detect nonlinear signals from microbubbles. It was found that nonlinear scattering from the microbubbles degrades the sensitivity of the binary encoded approach such that at high SNR there is no advantage in using these pulses over existing short-pulse PIAM. However, at lower SNR (<20 dB) the increased pulse length provides improved sensitivity without significant loss of spatial resolution, even under conditions in which the detection failed completely for existing approaches. The results also show that both the insonating acoustic pressure and resonance behavior of bubbles have an effect on the detection sensitivity and spatial resolution for the binary encoded approach. |
| | |
Authors:
|
Robert J Eckersley; Meng-Xing Tang; Kevin Chetty; Joseph V Hajnal |
Related Documents
:
|
17026369 - Cavitation bubble dynamics inside liquid drops in microgravity. 16857229 - Stable multibubble sonoluminescence bubble patterns. 21113089 - The precision of respiratory-gated delivery of synchrotron-based pulsed beam proton the... 17532249 - A theoretical study of hydrodynamic cavitation. 20330089 - Effects of quadrupole and octupole modes on coupled nonlinear bubble interactions. 21041109 - Characterization of an acoustic cavitation bubble structure at 230 khz. 16441049 - Writing 40 nm marks by using a beaked metallic plate near-field optical probe. 17748349 - Patterned condensation figures as optical diffraction gratings. 8794939 - A low-cost uv laser for flash photolysis of caged compounds. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-16 |
Journal Detail:
|
Title: Ultrasound in medicine & biology Volume: 33 ISSN: 0301-5629 ISO Abbreviation: Ultrasound Med Biol Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2007-10-30 Completed Date: 2008-04-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
|
Languages: eng Pagination: 1787-95 Citation Subset: IM |
Affiliation:
|
Imaging Sciences Department, Imperial College London, London, UK. r.eckersley@imperial.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biomechanics Contrast Media* Feasibility Studies Humans Image Interpretation, Computer-Assisted / methods* Microbubbles* Models, Theoretical Sensitivity and Specificity Ultrasonography / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of contrast enhanced ultrasound and contrast enhanced CT or MRI in monitoring percutaneou...
Next Document: Transient global amnesia: cerebral venous outflow impairment-insight from the abnormal flow patterns...