Document Detail


Microbleeds relate to altered amyloid-beta metabolism in Alzheimer's disease.
MedLine Citation:
PMID:  22118945     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cerebral microbleeds (MBs) may relate to amyloid in dementia. We selected 26 probable Alzheimer's disease (AD) patients with MBs, 26 age- and sex-matched AD patients without MBs, 11 vascular dementia (VaD) patients, and 22 patients with subjective complaints. We measured amyloid beta 1-42 (Aβ42) and 1-40 (Aβ40) in cerebrospinal fluid (CSF) and plasma, and blood-brain barrier (BBB) function using albumin ratios. CSF Aβ42 was lowest in AD with MBs, whereas Aβ40 was selectively decreased in VaD. In plasma, amyloid-beta was nonsignificantly elevated in VaD compared with controls. Higher albumin ratios in VaD suggested blood-brain barrier dysfunction. A MB pattern suggestive of cerebral amyloid angiopathy (CAA) related to lower CSF Aβ42, while a non-cerebral amyloid angiopathy specific MB distribution related to higher plasma Aβ40. Amyloid-beta is differentially implicated in AD with MBs and VaD. MB distribution related to different amyloid profiles, supporting distinct etiologies. Our results suggest that Aβ42 is retained in cerebrovasculature of AD patients with MBs, while in contrast, VaD patients may possibly drain amyloid.
Authors:
Jeroen D C Goos; Charlotte E Teunissen; Robert Veerhuis; Nicolaas A Verwey; Frederik Barkhof; Marinus A Blankenstein; Philip Scheltens; Wiesje M van der Flier
Related Documents :
20178715 - The significance of atypical morphology in the changes of spectrum of postinfectious gl...
21432575 - Borderline typical symptoms in adult patients with attention deficit/hyperactivity diso...
18390585 - Evaluation of a new algorithm in classification of systemic vasculitis.
18650595 - Successful management of idiopathic rapidly progressive glomerulonephritis with cortico...
10534335 - Natural history of liver disease in cystic fibrosis.
1396485 - Elevated plasma vitamers of vitamin b6 in patients with chronic renal failure on regula...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-25
Journal Detail:
Title:  Neurobiology of aging     Volume:  -     ISSN:  1558-1497     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Young Alzheimer patients show distinct regional changes of oscillatory brain dynamics.
Next Document:  Alternative splicing of mRNA in the molecular pathology of neurodegenerative diseases.