Document Detail


Microbiota conservation and BMI signatures in adult monozygotic twins.
MedLine Citation:
PMID:  23190729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human gastrointestinal (GI) tract microbiota acts like a virtual organ and is suggested to be of great importance in human energy balance and weight control. This study included 40 monozygotic (MZ) twin pairs to investigate the influence of the human genotype on GI microbiota structure as well as microbial signatures for differences in body mass index (BMI). Phylogenetic microarraying based on 16S rRNA genes demonstrated that MZ twins have more similar microbiotas compared with unrelated subjects (P<0.001), which allowed the identification of 35 genus-like microbial groups that are more conserved between MZ twins. Half of the twin pairs were selected on discordance in terms of BMI, which revealed an inverse correlation between Clostridium cluster IV diversity and BMI. Furthermore, relatives of Eubacterium ventriosum and Roseburia intestinalis were positively correlated to BMI differences, and relatives of Oscillospira guillermondii were negatively correlated to BMI differences. Lower BMI was associated with a more abundant network of primary fiber degraders, while a network of butyrate producers was more prominent in subjects with higher BMI. Combined with higher butyrate and valerate contents in the fecal matter of higher BMI subjects, the difference in microbial networks suggests a shift in fermentation patterns at the end of the colon, which could affect human energy homeostasis.
Authors:
Sebastian Tims; Catherine Derom; Daisy M Jonkers; Robert Vlietinck; Wim H Saris; Michiel Kleerebezem; Willem M de Vos; Erwin G Zoetendal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study     Date:  2012-11-29
Journal Detail:
Title:  The ISME journal     Volume:  7     ISSN:  1751-7370     ISO Abbreviation:  ISME J     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-19     Completed Date:  2013-09-30     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  101301086     Medline TA:  ISME J     Country:  England    
Other Details:
Languages:  eng     Pagination:  707-17     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index*
DNA, Bacterial / genetics
Dietary Fiber / metabolism
Feces / microbiology
Gastrointestinal Tract / microbiology*
Gram-Positive Endospore-Forming Rods / classification,  isolation & purification*,  metabolism
Humans
Metagenome*
Phylogeny
RNA, Ribosomal, 16S / genetics
Twins, Monozygotic*
Chemical
Reg. No./Substance:
0/DNA, Bacterial; 0/RNA, Ribosomal, 16S
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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