Document Detail


The microbiome in wound repair and tissue fibrosis.
MedLine Citation:
PMID:  23042513     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bacterial colonization occurs in all wounds, chronic or acute, and the break in epithelium integrity that defines a wound impairs the forces that shape and constrain the microbiome at that site. This review highlights the interactions between bacterial communities in the wound and the ultimate resolution of the wound or development of fibrotic lesions. Chronic wounds support complex microbial communities comprising a wide variety of bacterial phyla, genera, and species, including some fastidious anaerobic bacteria not identified using culture-based methods. Thus, the complexity of bacterial communities in wounds has historically been underestimated. There are a number of intriguing possibilities to explain these results that may also provide novel insights into changes and adaptation of bacterial metabolic networks in inflamed and wounded mucosa, including the critical role of biofilm formation. It is well accepted that the heightened state of activation of host cells in a wound that is driven by the microbiota can certainly lead to detrimental effects on wound regeneration, but the microbiota of the wound may also have beneficial effects on wound healing. Studies in experimental systems have clearly demonstrated a beneficial effect for members of the gut microbiota on regulation of systemic inflammation, which could also impact wound healing at sites outside the gastrointestinal tract. The utilization of culture-independent microbiology to characterize the microbiome of wounds and surrounding mucosa has raised many intriguing questions regarding previously held notions about the cause and effect relationships between bacterial colonization and wound repair and mechanisms involved in this symbiotic relationship.
Authors:
Brittan S Scales; Gary B Huffnagle
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-11-29
Journal Detail:
Title:  The Journal of pathology     Volume:  229     ISSN:  1096-9896     ISO Abbreviation:  J. Pathol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-12     Completed Date:  2013-02-07     Revised Date:  2014-01-01    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  323-31     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Physiological Phenomena*
Biofilms
Fibrosis
Gastrointestinal Tract / microbiology
Humans
Metagenome*
Symbiosis
Wound Healing*
Grant Support
ID/Acronym/Agency:
P30 DK034933/DK/NIDDK NIH HHS; P30DK034933/DK/NIDDK NIH HHS; R01HL114447/HL/NHLBI NIH HHS; R21 AI087869/AI/NIAID NIH HHS; R21AI087869/AI/NIAID NIH HHS; T32AI007528/AI/NIAID NIH HHS; U19 AI090871/AI/NIAID NIH HHS; U19AI090871/AI/NIAID NIH HHS
Comments/Corrections

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