Document Detail


Microbicide research and development--where to?
MedLine Citation:
PMID:  11590526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Against the backdrop of increasing numbers of HIV infections in women and the limitations of current safer sex messages, several calls have been made for the development of women-initiated methods of prevention as an essential component of the armamentarium to reduce women's vulnerability of acquiring infection with HIV. An effective microbicide is a critical survival tool in instances and situations where existing proven prevention strategies have failed to be adopted. METHOD: The results of published N-9 clinical trials in terms of anti-HIV activity, safety data, and anti-sexually transmitted infection (STI) activity are discussed. RESULTS: There is no evidence of efficacy against HIV in three clinical trials, there is scanty evidence for protection against STIs, and there is considerable evidence of dose-related adverse effects. CONCLUSION: During this time, a vast array of potential microbicides with differing modes of action have been discovered, and some have undergone preclinical and early clinical testing. Effort, time, and resources might be better spent on advancing preclinical and clinical testing of these other candidate microbicides.
Authors:
R Rustomjee; Q Abdool Karim
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Publication Detail:
Type:  Editorial    
Journal Detail:
Title:  HIV clinical trials     Volume:  2     ISSN:  1528-4336     ISO Abbreviation:  HIV Clin Trials     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-10-08     Completed Date:  2002-01-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100936377     Medline TA:  HIV Clin Trials     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents
Anti-Infective Agents / administration & dosage*,  adverse effects,  therapeutic use
Chlamydia Infections / prevention & control
Chlamydia trachomatis / drug effects
Female
Gonorrhea / prevention & control
HIV Infections / prevention & control*
HIV-1 / drug effects*
Humans
Neisseria gonorrhoeae / drug effects
Nonoxynol / administration & dosage*,  adverse effects,  therapeutic use
Randomized Controlled Trials as Topic / methods*
Research Design
Sexually Transmitted Diseases / prevention & control
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 26027-38-3/Nonoxynol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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