| Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264. | |
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MedLine Citation:
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PMID: 22800913 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Biotransformation of ursolic acid by the filamentous fungus Syncephalastrum racemosum (Cohn) Schroter AS 3.264 yielded five metabolites. Their structures were identified as 3β,21β-dihydroxy-urs-11-en-28-oic acid-13-lactone, 3β,7β,21β-trihydroxy-urs-11-en-28-oic acid-13-lactone, 1β,3β-dihydroxy-urs-12-en-21-one-28-oic acid, 1β,3β,21β-trihydroxy-urs-12-en-28-oic acid and 11,26-epoxy-3β,21β-dihydroxy-urs-12-en-28-oic acid based on NMR and MS spectroscopic analyses. The condensation reactions to form 28-oic acid-13-lactone ring and 11,26-epoxy ring are not frequently seen for the biotransformation of triterpenoids. One compound showed moderate inhibitory activity against protein tyrosine phosphatase 1B (PTP1B). |
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Authors:
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Fei-Xia Huang; Wen-Zhi Yang; Fei Ye; Jin-Ying Tian; Hong-Bo Hu; Lin-Min Feng; De-An Guo; Min Ye |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-14 |
Journal Detail:
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Title: Phytochemistry Volume: - ISSN: 1873-3700 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151434 Medline TA: Phytochemistry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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