Document Detail

Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264.
MedLine Citation:
PMID:  22800913     Owner:  NLM     Status:  Publisher    
Biotransformation of ursolic acid by the filamentous fungus Syncephalastrum racemosum (Cohn) Schroter AS 3.264 yielded five metabolites. Their structures were identified as 3β,21β-dihydroxy-urs-11-en-28-oic acid-13-lactone, 3β,7β,21β-trihydroxy-urs-11-en-28-oic acid-13-lactone, 1β,3β-dihydroxy-urs-12-en-21-one-28-oic acid, 1β,3β,21β-trihydroxy-urs-12-en-28-oic acid and 11,26-epoxy-3β,21β-dihydroxy-urs-12-en-28-oic acid based on NMR and MS spectroscopic analyses. The condensation reactions to form 28-oic acid-13-lactone ring and 11,26-epoxy ring are not frequently seen for the biotransformation of triterpenoids. One compound showed moderate inhibitory activity against protein tyrosine phosphatase 1B (PTP1B).
Fei-Xia Huang; Wen-Zhi Yang; Fei Ye; Jin-Ying Tian; Hong-Bo Hu; Lin-Min Feng; De-An Guo; Min Ye
Related Documents :
23302523 - A new feruloyl tyramine glycoside from the roots of achyranthes bidentata.
15105103 - Identification and characterization of inhibitors of bacterial enoyl-acyl carrier prote...
6799643 - Inhibition of acid secretion in isolated canine parietal cells by prostaglandins.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-14
Journal Detail:
Title:  Phytochemistry     Volume:  -     ISSN:  1873-3700     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prenylated flavonoids from Desmodium caudatum and evaluation of their anti-MRSA activity.
Next Document:  Comparative Investigation of Fourier Transform Infrared (FT-IR) Spectroscopy and X-ray Diffraction (...