| Microbial transformation of pyrethrosin. | |
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MedLine Citation:
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PMID: 11520238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microbial transformation of the germacranolide pyrethrosin (1) using Rhizopus nigricans NRRL 1477 has resulted in the isolation of 6 alpha-acetoxy-1 beta,4 alpha-dihydroxy-5,7 alpha H,8 beta H-eudesm-11 beta,13-dihydro-8,12-olide (5), a new eudesmanolide-type metabolite, in addition to the previously reported eudesmanolides: 2, 3, 4, and 6. The structure elucidation of these metabolites was based primarily on 1D and 2D NMR analyses. The isolated metabolites exhibited cytotoxic, antifungal, and antiprotozoal activities. |
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Authors:
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A M Galal |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of natural products Volume: 64 ISSN: 0163-3864 ISO Abbreviation: J. Nat. Prod. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-08-24 Completed Date: 2001-10-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1098-9 Citation Subset: IM |
Affiliation:
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National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA. amgalalv@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Infective Agents / chemistry, isolation & purification*, pharmacology Antifungal Agents / chemistry, isolation & purification*, pharmacology Antimalarials / chemistry, isolation & purification*, pharmacology Antineoplastic Agents, Phytogenic / chemistry, isolation & purification*, pharmacology Biotransformation Candida albicans / drug effects Carcinoma, Squamous Cell Cryptococcus neoformans / drug effects Female Humans Magnetic Resonance Spectroscopy Melanoma Molecular Structure Ovarian Neoplasms Plasmodium falciparum / drug effects Pyrethrins / chemistry, metabolism* Rhizopus / metabolism Sesquiterpenes / chemistry, isolation & purification*, metabolism*, pharmacology Sesquiterpenes, Eudesmane* Tumor Cells, Cultured / drug effects |
| Chemical | |
Reg. No./Substance:
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0/6alpha-acetoxy-1beta,4alpha-dihydroxy-5,7alpha H,8 beta H-eudesm-11beta,13-dihydro-8,12-olide; 0/Anti-Infective Agents; 0/Antifungal Agents; 0/Antimalarials; 0/Antineoplastic Agents, Phytogenic; 0/Pyrethrins; 0/Sesquiterpenes; 0/Sesquiterpenes, Eudesmane; 28272-18-6/pyrethrosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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