Document Detail

Microbial transformation of pyrethrosin.
MedLine Citation:
PMID:  11520238     Owner:  NLM     Status:  MEDLINE    
Microbial transformation of the germacranolide pyrethrosin (1) using Rhizopus nigricans NRRL 1477 has resulted in the isolation of 6 alpha-acetoxy-1 beta,4 alpha-dihydroxy-5,7 alpha H,8 beta H-eudesm-11 beta,13-dihydro-8,12-olide (5), a new eudesmanolide-type metabolite, in addition to the previously reported eudesmanolides: 2, 3, 4, and 6. The structure elucidation of these metabolites was based primarily on 1D and 2D NMR analyses. The isolated metabolites exhibited cytotoxic, antifungal, and antiprotozoal activities.
A M Galal
Related Documents :
7682318 - Pregnancy associated with primary hepatocellular carcinoma.
1382388 - Elevated levels of midtrimester maternal serum alpha-fetoprotein are associated with pr...
15695018 - Soman poisoning increases neural progenitor proliferation and induces long-term glial a...
16147728 - Correlation of abnormal second trimester maternal serum alpha-fetoprotein (msafp) level...
8355928 - Pregnancy in heart transplant recipients: management and outcome.
21851938 - Multinucleation of a sibling blastomere on day 2 suggests unsuitability for embryo tran...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of natural products     Volume:  64     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-24     Completed Date:  2001-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1098-9     Citation Subset:  IM    
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Infective Agents / chemistry,  isolation & purification*,  pharmacology
Antifungal Agents / chemistry,  isolation & purification*,  pharmacology
Antimalarials / chemistry,  isolation & purification*,  pharmacology
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification*,  pharmacology
Candida albicans / drug effects
Carcinoma, Squamous Cell
Cryptococcus neoformans / drug effects
Magnetic Resonance Spectroscopy
Molecular Structure
Ovarian Neoplasms
Plasmodium falciparum / drug effects
Pyrethrins / chemistry,  metabolism*
Rhizopus / metabolism
Sesquiterpenes / chemistry,  isolation & purification*,  metabolism*,  pharmacology
Sesquiterpenes, Eudesmane*
Tumor Cells, Cultured / drug effects
Reg. No./Substance:
0/6alpha-acetoxy-1beta,4alpha-dihydroxy-5,7alpha H,8 beta H-eudesm-11beta,13-dihydro-8,12-olide; 0/Anti-Infective Agents; 0/Antifungal Agents; 0/Antimalarials; 0/Antineoplastic Agents, Phytogenic; 0/Pyrethrins; 0/Sesquiterpenes; 0/Sesquiterpenes, Eudesmane; 28272-18-6/pyrethrosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Samioside, a new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities ...
Next Document:  A novel modified pterin from a Eudistoma species ascidian.