Document Detail


Microbial transformation of pyrethrosin.
MedLine Citation:
PMID:  11520238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microbial transformation of the germacranolide pyrethrosin (1) using Rhizopus nigricans NRRL 1477 has resulted in the isolation of 6 alpha-acetoxy-1 beta,4 alpha-dihydroxy-5,7 alpha H,8 beta H-eudesm-11 beta,13-dihydro-8,12-olide (5), a new eudesmanolide-type metabolite, in addition to the previously reported eudesmanolides: 2, 3, 4, and 6. The structure elucidation of these metabolites was based primarily on 1D and 2D NMR analyses. The isolated metabolites exhibited cytotoxic, antifungal, and antiprotozoal activities.
Authors:
A M Galal
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of natural products     Volume:  64     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-24     Completed Date:  2001-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1098-9     Citation Subset:  IM    
Affiliation:
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA. amgalalv@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents / chemistry,  isolation & purification*,  pharmacology
Antifungal Agents / chemistry,  isolation & purification*,  pharmacology
Antimalarials / chemistry,  isolation & purification*,  pharmacology
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification*,  pharmacology
Biotransformation
Candida albicans / drug effects
Carcinoma, Squamous Cell
Cryptococcus neoformans / drug effects
Female
Humans
Magnetic Resonance Spectroscopy
Melanoma
Molecular Structure
Ovarian Neoplasms
Plasmodium falciparum / drug effects
Pyrethrins / chemistry,  metabolism*
Rhizopus / metabolism
Sesquiterpenes / chemistry,  isolation & purification*,  metabolism*,  pharmacology
Sesquiterpenes, Eudesmane*
Tumor Cells, Cultured / drug effects
Chemical
Reg. No./Substance:
0/6alpha-acetoxy-1beta,4alpha-dihydroxy-5,7alpha H,8 beta H-eudesm-11beta,13-dihydro-8,12-olide; 0/Anti-Infective Agents; 0/Antifungal Agents; 0/Antimalarials; 0/Antineoplastic Agents, Phytogenic; 0/Pyrethrins; 0/Sesquiterpenes; 0/Sesquiterpenes, Eudesmane; 28272-18-6/pyrethrosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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