Document Detail


Microbial regulation of allergic responses to food.
MedLine Citation:
PMID:  22941410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of food allergy in developed countries is rising at a rate that cannot be attributed to genetic variation alone. In this review, we discuss the environmental factors that may contribute to the increasing prevalence of potentially fatal anaphylactic responses to food. Decreased exposure to enteric infections due to advances in vaccination and sanitation, along with the adoption of high-fat (Western) diets, antibiotic use, Cesarean birth, and formula feeding of infants, have all been implicated in altering the enteric microbiome away from its ancestral state. This collection of resident commensal microbes performs many important physiological functions and plays a central role in the development of the immune system. We hypothesize that alterations in the microbiome interfere with immune system maturation, resulting in impairment of IgA production, reduced abundance of regulatory T cells, and Th2-skewing of baseline immune responses which drive aberrant responses to innocuous (food) antigens.
Authors:
Taylor Feehley; Andrew T Stefka; Severine Cao; Cathryn R Nagler
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-09-01
Journal Detail:
Title:  Seminars in immunopathology     Volume:  34     ISSN:  1863-2300     ISO Abbreviation:  Semin Immunopathol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-01-15     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  101308769     Medline TA:  Semin Immunopathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  671-88     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anaphylaxis* / epidemiology,  immunology,  microbiology
Animals
Antigens / immunology
Developed Countries
Food Hypersensitivity* / epidemiology,  immunology,  microbiology
Humans
Immunoglobulin A / immunology
Incidence
Risk Factors
Th2 Cells / immunology
Grant Support
ID/Acronym/Agency:
P30 DK042086/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antigens; 0/Immunoglobulin A
Comments/Corrections

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