| Microbial regulation of allergic responses to food. | |
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MedLine Citation:
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PMID: 22941410 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The incidence of food allergy in developed countries is rising at a rate that cannot be attributed to genetic variation alone. In this review, we discuss the environmental factors that may contribute to the increasing prevalence of potentially fatal anaphylactic responses to food. Decreased exposure to enteric infections due to advances in vaccination and sanitation, along with the adoption of high-fat (Western) diets, antibiotic use, Cesarean birth, and formula feeding of infants, have all been implicated in altering the enteric microbiome away from its ancestral state. This collection of resident commensal microbes performs many important physiological functions and plays a central role in the development of the immune system. We hypothesize that alterations in the microbiome interfere with immune system maturation, resulting in impairment of IgA production, reduced abundance of regulatory T cells, and Th2-skewing of baseline immune responses which drive aberrant responses to innocuous (food) antigens. |
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Authors:
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Taylor Feehley; Andrew T Stefka; Severine Cao; Cathryn R Nagler |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-1 |
Journal Detail:
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Title: Seminars in immunopathology Volume: - ISSN: 1863-2300 ISO Abbreviation: Semin Immunopathol Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101308769 Medline TA: Semin Immunopathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Committee on Immunology and Department of Pathology, University of Chicago, Chicago, IL, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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