| Microbial quorum sensing: a tool or a target for antimicrobial therapy? | |
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MedLine Citation:
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PMID: 19594442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inter-cell communication aided by released chemical signals when cell density reaches a critical concentration has been investigated for over 30 years as quorum sensing. Originally discovered in Gram-negative bacteria, quorum-sensing systems have also been studied extensively in Gram-positive bacteria and dimorphic fungi. Microbial communities communicating via quorum sensing employ various chemical signals to supervise their surrounding environment, alter genetic expression and gain advantage over their competitors. These signals vary from acylhomoserine lactones to small modified or unmodified peptides to complex gamma-butyrolactone molecules. The scope of this review is to give an insight into some of the quorum-sensing systems now known and to explore their role in microbial physiology and development of pathogenesis. Particular attention will be dedicated to the signalling molecules involved in quorum-sensing-mediated processes and the potential shown by some of their natural and synthetic analogues in the treatment of infections triggered by quorum sensing. |
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Authors:
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Sheetal Raina; Daniela De Vizio; Mark Odell; Mark Clements; Sophie Vanhulle; Tajalli Keshavarz |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-07-14 |
Journal Detail:
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Title: Biotechnology and applied biochemistry Volume: 54 ISSN: 1470-8744 ISO Abbreviation: Biotechnol. Appl. Biochem. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-07-14 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609465 Medline TA: Biotechnol Appl Biochem Country: England |
Other Details:
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Languages: eng Pagination: 65-84 Citation Subset: IM |
Affiliation:
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Cell Communication Research Group, Department of Molecular and Applied Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents Gram-Negative Bacteria / pathogenicity, physiology* Gram-Positive Bacteria / pathogenicity, physiology* Homoserine / analogs & derivatives, physiology Lactones Models, Biological* Quorum Sensing / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Lactones; 0/N-octanoylhomoserine lactone; 498-19-1/Homoserine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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