| Microbial production of propionic acid from propionibacteria: Current state, challenges and perspectives. | |
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MedLine Citation:
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PMID: 22299651 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Propionic acid (PA) is an important building block chemical and finds a variety of applications in organic synthesis, food, feeding stuffs, perfume, paint and pharmaceutical industries. Presently, PA is mainly produced by petrochemical route. With the continuous increase in oil prices, public concern about environmental pollution, and the consumers' desire for bio-based natural and green ingredients in foods and pharmaceuticals, PA production from propionibacteria has attracted considerable attention, and substantial progresses have been made on microbial PA production. However, production of PA by propionibacteria is facing challenges such as severe inhibition of end-products during cell growth and the formation of by-products (acetic acid and succinic acid). The integration of reverse metabolic engineering and systematic metabolic engineering provides an opportunity to significantly improve the acid tolerance of propionibacteria and reduce the formation of by-products, and makes it feasible to strengthen the commercial competition of biotechnological PA production from propionibacteria to be comparable to the petrochemical route. |
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Authors:
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Long Liu; Yunfeng Zhu; Jianghua Li; Miao Wang; Pengsoon Lee; Guocheng Du; Jian Chen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-3 |
Journal Detail:
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Title: Critical reviews in biotechnology Volume: - ISSN: 1549-7801 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505177 Medline TA: Crit Rev Biotechnol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University , Wuxi 214122 , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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