Document Detail

Microbial production of L-ascorbic acid from D-sorbitol, L-sorbose, L-gulose, and L-sorbosone by Ketogulonicigenium vulgare DSM 4025.
MedLine Citation:
PMID:  15785002     Owner:  NLM     Status:  MEDLINE    
Ketogulonicigenium vulgare DSM 4025, known as a 2-keto-L-gulonic acid producing strain from L-sorbose via L-sorbosone, surprisingly produced L-ascorbic acid from D-sorbitol, L-sorbose, L-gulose, and L-sorbosone as the substrate under a growing or resting condition. As the best result, K. vulgare DSM 4025 produced 1.37 g per liter of L-AA from 5.00 g per liter of L-sorbosone during 4 h incubation time at 30 degrees C under the resting cell condition having 5.70 g per liter of wet cells. The precursor of L-AA formation from D-sorbitol and L-sorbose, except for L-gulose, was thought to be the putative furanose form of L-sorbosone. This is the first time it is reported that bacteria can produce vitamin C via L-sorbosone.
Teruhide Sugisawa; Taro Miyazaki; Tatsuo Hoshino
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  69     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-23     Completed Date:  2005-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  659-62     Citation Subset:  IM    
Biotechnology R&D, DSM Nutritional Products Ltd., Basel, Switzerland.
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MeSH Terms
Ascorbic Acid / biosynthesis*
Gluconobacter oxydans / metabolism*
Hexoses / metabolism*
Sorbitol / metabolism*
Sorbose / analogs & derivatives*,  metabolism*
Reg. No./Substance:
0/Hexoses; 19163-87-2/gulose; 25990-59-4/sorbosone; 3615-39-2/Sorbose; 50-70-4/Sorbitol; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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