| Microbial induction of B and T cell areas in rabbit appendix. | |
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MedLine Citation:
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PMID: 18329710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gut-associated lymphoid tissue (GALT) development requires interaction with the intestinal microbiota. Because murine secondary lymphoid tissue development is driven by positive feedback interactions between B cells and stromal cells, we used in situ hybridization to determine whether intestinal commensals influence such interactions during rabbit appendix development. The features of positive feedback interactions we examined (CXCL13 mRNA expression, B cell accumulation and FDC differentiation) increased during early follicle development, but stalled in the absence of intestinal commensals. These features were reinitiated by commensals that stimulated follicle development and intrafollicular B cell proliferation. Our results suggest that rabbit appendix follicles develop in two phases: an initial phase of B cell recruitment to nascent follicles, possibly through positive feedback interactions, and a subsequent phase of intrafollicular B cell proliferation stimulated by intestinal commensals. In addition, we found that intestinal commensals stimulate appendix CCL21 mRNA expression and T cell area formation. |
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Authors:
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Nicholas B Hanson; Dennis K Lanning |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-02-25 |
Journal Detail:
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Title: Developmental and comparative immunology Volume: 32 ISSN: 0145-305X ISO Abbreviation: Dev. Comp. Immunol. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-03-28 Completed Date: 2008-06-24 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7708205 Medline TA: Dev Comp Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 980-91 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appendix / immunology*, microbiology B-Lymphocytes / physiology* Chemokine CCL21 / genetics Chemokine CXCL13 / genetics Intestines / microbiology* Lymphocyte Activation Lymphotoxin beta Receptor / physiology RNA, Messenger / analysis Rabbits Receptors, Complement 3b / analysis Receptors, Tumor Necrosis Factor, Type I / physiology Signal Transduction T-Lymphocytes / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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1 R01 AI 49458-01A1/AI/NIAID NIH HHS; R01 AI049458-04/AI/NIAID NIH HHS; R01 AI049458-05/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CCL21; 0/Chemokine CXCL13; 0/Lymphotoxin beta Receptor; 0/RNA, Messenger; 0/Receptors, Complement 3b; 0/Receptors, Tumor Necrosis Factor, Type I |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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