Document Detail

Microbial induction of B and T cell areas in rabbit appendix.
MedLine Citation:
PMID:  18329710     Owner:  NLM     Status:  MEDLINE    
Gut-associated lymphoid tissue (GALT) development requires interaction with the intestinal microbiota. Because murine secondary lymphoid tissue development is driven by positive feedback interactions between B cells and stromal cells, we used in situ hybridization to determine whether intestinal commensals influence such interactions during rabbit appendix development. The features of positive feedback interactions we examined (CXCL13 mRNA expression, B cell accumulation and FDC differentiation) increased during early follicle development, but stalled in the absence of intestinal commensals. These features were reinitiated by commensals that stimulated follicle development and intrafollicular B cell proliferation. Our results suggest that rabbit appendix follicles develop in two phases: an initial phase of B cell recruitment to nascent follicles, possibly through positive feedback interactions, and a subsequent phase of intrafollicular B cell proliferation stimulated by intestinal commensals. In addition, we found that intestinal commensals stimulate appendix CCL21 mRNA expression and T cell area formation.
Nicholas B Hanson; Dennis K Lanning
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-02-25
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  32     ISSN:  0145-305X     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-28     Completed Date:  2008-06-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  980-91     Citation Subset:  IM    
Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, USA.
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MeSH Terms
Appendix / immunology*,  microbiology
B-Lymphocytes / physiology*
Chemokine CCL21 / genetics
Chemokine CXCL13 / genetics
Intestines / microbiology*
Lymphocyte Activation
Lymphotoxin beta Receptor / physiology
RNA, Messenger / analysis
Receptors, Complement 3b / analysis
Receptors, Tumor Necrosis Factor, Type I / physiology
Signal Transduction
T-Lymphocytes / physiology*
Grant Support
1 R01 AI 49458-01A1/AI/NIAID NIH HHS; R01 AI049458-04/AI/NIAID NIH HHS; R01 AI049458-05/AI/NIAID NIH HHS
Reg. No./Substance:
0/Chemokine CCL21; 0/Chemokine CXCL13; 0/Lymphotoxin beta Receptor; 0/RNA, Messenger; 0/Receptors, Complement 3b; 0/Receptors, Tumor Necrosis Factor, Type I

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