Document Detail

Microbial hydroxylation of 5-anilino-1,2,3,4-thiatriazole.
MedLine Citation:
PMID:  4699219     Owner:  NLM     Status:  MEDLINE    
Two hundred eighty-five fungi, including 100 basidiomycetes and 35 yeasts, 75 actinomycetes, and 40 bacteria were screened for their ability to convert 5-anilino-1,2,3,4-thiatriazole (AT) to 5-(p-hydroxyanilino)-1,2,3,4-thiatriazole (p-HT). Eleven cultures were found that formed p-HT, which was isolated and whose structure was determined. Aspergillus tamarii NRRL 3280 formed 8.6 g of p-HT/liter from 10 g of AT/liter (78.9% conversion) in shaken flasks and 4.57 g of p-HT/liter from 6 g of AT/liter (69.8% conversion) in 30-liter fermentors. Washed cells of A. tamarii NRRL 3280 also carried out this conversion. 5-(o-hydroxyanilino)-1,2,3,4-thiatriazole (o-HT) was identified as a second product formed by Aspergillus terreus NRRL 1960.
R J Theriault; T H Longfield
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied microbiology     Volume:  25     ISSN:  0003-6919     ISO Abbreviation:  Appl Microbiol     Publication Date:  1973 Apr 
Date Detail:
Created Date:  1973-06-21     Completed Date:  1973-06-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7605802     Medline TA:  Appl Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  606-11     Citation Subset:  IM    
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MeSH Terms
Aniline Compounds / metabolism*
Antihypertensive Agents / biosynthesis*,  isolation & purification
Aspergillus / metabolism
Bacteria / metabolism*
Chemical Phenomena
Chromatography, Thin Layer
Culture Media
Fungi / metabolism*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Species Specificity
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Triazoles / metabolism*
Reg. No./Substance:
0/Aniline Compounds; 0/Antihypertensive Agents; 0/Culture Media; 0/Triazoles

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