Document Detail


Microbial equol production attenuates colonic methanogenesis and sulphidogenesis in vitro.
MedLine Citation:
PMID:  20298796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hydrogen gas produced during colonic fermentation is excreted in breath and flatus, or removed by hydrogen-consuming bacteria such as methanogens and sulphate-reducing bacteria. However, recent research has shown that H2 is also consumed by equol-producing bacteria during the reduction of daidzein into equol. In this study, the interactions between methanogens, sulphate-reducing, and equol-producing bacteria were investigated under in vitro simulated intestinal conditions. In the presence of daidzein, the equol-producing bacterial consortium EPC4 gave rise to equol production in cultures of Methanobrevibacter smithii or Desulfovibrio sp. as well as in faecal samples with methanogenic or sulphate-reducing abilities. Moreover, this supplementation significantly (P<0.001) decreased the methanogenesis and sulphidogenesis. The attenuation did not occur in the absence of a daidzein source. Additionally, there was no influence of soy germ powder, daidzein or equol as such, excluding a possible inhibition by these compounds. Finally, a stronger decrease was observed with increasing amounts of EPC4 and a constant equol production, suggesting that the observed effect was only partly caused by the action of daidzein as a hydrogen sink. These findings are of relevance since abdominal discomfort such as bloating and flatulence, are related to colonic gas production, whereas equol has potential health benefits.
Authors:
Selin Bolca; Willy Verstraete
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-16
Journal Detail:
Title:  Anaerobe     Volume:  16     ISSN:  1095-8274     ISO Abbreviation:  Anaerobe     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505216     Medline TA:  Anaerobe     Country:  England    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Ltd. All rights reserved.
Affiliation:
Laboratory of Microbial Ecology and Technology (LabMET), Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium. selin.bolca@ugent.be
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MeSH Terms
Descriptor/Qualifier:
Colon / metabolism*,  microbiology*
Culture Media
Desulfovibrio / metabolism
Enterococcus faecium / growth & development,  metabolism
Euryarchaeota / growth & development,  metabolism
Feces / microbiology
Female
Humans
Hydrogen / metabolism
Isoflavones / biosynthesis*,  metabolism
Lactobacillus / growth & development,  metabolism*
Methane / metabolism*
Methanobrevibacter / growth & development,  metabolism
Middle Aged
Sulfides / metabolism*
Veillonella / growth & development,  metabolism
Chemical
Reg. No./Substance:
0/Culture Media; 0/Isoflavones; 0/Sulfides; 1333-74-0/Hydrogen; 486-66-8/daidzein; 531-95-3/equol; 74-82-8/Methane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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