| Microbial entry through caveolae: variations on a theme. | |
| | |
MedLine Citation:
|
PMID: 12464009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Caveolae and lipid rafts are increasingly being recognized as a significant portal of entry into host cells for a wide variety of pathogenic microorganisms. Entry through this mechanism appears to afford the microbes protection from degradation in lysosomes, though the level to which each microbe actively participates in avoiding lysosomal fusion may vary. Other possible variations in microbial entry through caveolae or lipid rafts may include (i) the destination of trafficking after entry and (ii) how actively the microbe contributes to the caveolae lipid/raft mediated entry. It seems that, though a wide variety of microorganisms are capable of utilizing caveolae/lipid rafts in various stages of their intracellular lifestyle, there can be distinct differences in how each microbe interacts with these structures. By studying these variations, we may learn more about the normal functioning of these cellular microdomains, and perhaps of more immediate importance, how to incorporate the use of these structures into the treatment of both infectious and non-infectious disease. |
| | |
Authors:
|
Matthew J Duncan; Jeoung-Sook Shin; Soman N Abraham |
Related Documents
:
|
18530109 - High environmental quality (hqe), the giacademe approach. 1081809 - Studies on coagulation and fibrinolysis in pregnancy, with special reference to cold ac... 2981599 - Serial estimation of serum angiotensin converting enzyme activity during and after preg... 6430089 - The interactions of exercise and pregnancy: a review. 2070529 - Medical treatment of chronic otitis media: steroid or antibiotic with steroid ear-drops? 2788219 - Modulation of the immunosuppressive activities by blastocoelic fluid during rabbit preg... 2776199 - Uncertain gestation and pregnancy outcome. 18927129 - Mannose-binding lectin-2 genotypes and recurrent late pregnancy losses. 16728079 - Transuterine sperm transport is not affected by bilateral asymmetry of the reproductive... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Cellular microbiology Volume: 4 ISSN: 1462-5814 ISO Abbreviation: Cell. Microbiol. Publication Date: 2002 Dec |
Date Detail:
|
Created Date: 2002-12-04 Completed Date: 2003-02-07 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 100883691 Medline TA: Cell Microbiol Country: England |
Other Details:
|
Languages: eng Pagination: 783-91 Citation Subset: IM |
Affiliation:
|
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bacteria / pathogenicity* Bacterial Infections / microbiology Caveolae* / microbiology, parasitology, virology Eukaryota / pathogenicity* Humans Protozoan Infections / parasitology Virus Diseases / virology Viruses / pathogenicity* |
| Grant Support | |
ID/Acronym/Agency:
|
AI 50021/AI/NIAID NIH HHS; DK 50814/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is...
Next Document: PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus con...