Document Detail

Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women.
MedLine Citation:
PMID:  17521469     Owner:  NLM     Status:  MEDLINE    
Hop-derived food supplements and beers contain the prenylflavonoids xanthohumol (X), isoxanthohumol (IX) and the very potent phyto-oestrogen (plant-derived oestrogen mimic) 8-prenylnaringenin (8-PN). The weakly oestrogenic IX can be bioactivated via O-demethylation to 8-PN. Since IX usually predominates over 8-PN, human subjects may be exposed to increased doses of 8-PN. A dietary intervention trial with fifty healthy post-menopausal Caucasian women was undertaken. After a 4 d washout period, participants delivered faeces, blank urine and breath samples. Next, they started a 5 d treatment with hop-based supplements that were administered three times per d and on the last day, a 24 h urine sample was collected. A semi-quantitative FFQ was used to estimate fat, fibre, alcohol, caffeine and theobromine intakes. The recoveries of IX, 8-PN and X in the urine were low and considerable inter-individual variations were observed. A five-fold increase in the dosage of IX without change in 8-PN concentration resulted in a significant lower IX recovery and a higher 8-PN recovery. Classification of the subjects into poor (60%), moderate (25%) and strong (15%) 8-PN producers based on either urinary excretion or microbial bioactivation capacity gave comparable results. Recent antibiotic therapy seemed to affect the 8-PN production negatively. A positive trend between methane excretion and 8-PN production was observed. Strong 8-PN producers consumed less alcohol and had a higher theobromine intake. From this study we conclude that in vivo O-demethylation of IX increases the oestrogenic potency of hop-derived products.
Selin Bolca; Sam Possemiers; Veerle Maervoet; Inge Huybrechts; Arne Heyerick; Stefaan Vervarcke; Herman Depypere; Denis De Keukeleire; Marc Bracke; Stefaan De Henauw; Willy Verstraete; Tom Van de Wiele
Related Documents :
3027719 - Lithium effects on adjunctive alcohol consumption. ii: effects of adding concurrent shock.
25394229 - Effect of rooibos (aspalathus linearis) on growth control of clostridium perfringens an...
9154709 - Sports supplement drinks and dental health in competitive swimmers and cyclists.
3689549 - The structure of the alcohol industry as it relates to transportation issues.
11198709 - Genetic and environmental influences on alcohol metabolism in humans.
11838919 - A longitudinal model of intake symptomatology, aa participation and outcome: retrospect...
18174099 - A population-based study of preschoolers' food neophobia and its associations with food...
1319589 - Bombesin-induced hypothermia and hypophagia are associated with plasma metabolic fuel a...
19810019 - Influence of thermal processing on ige reactivity to lentil and chickpea proteins.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-23
Journal Detail:
Title:  The British journal of nutrition     Volume:  98     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-11     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  950-9     Citation Subset:  IM    
Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Bacterial Agents / pharmacology
Dietary Supplements*
Feces / chemistry,  microbiology
Flavanones / biosynthesis*,  urine
Gastrointestinal Tract / microbiology
Methane / biosynthesis
Middle Aged
Phytoestrogens / metabolism
Postmenopause / physiology*
Propiophenones / urine
Xanthones / urine
Reg. No./Substance:
0/8-prenylnaringenin; 0/Anti-Bacterial Agents; 0/Flavanones; 0/Phytoestrogens; 0/Propiophenones; 0/Xanthones; 0/isoxanthohumol; 6754-58-1/xanthohumol; 74-82-8/Methane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Validation of a food frequency questionnaire to assess folate intake of Dutch elderly people.
Next Document:  Relationships between acceptance of sour taste and fruit intakes in 18-month-old infants.