Document Detail


Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women.
MedLine Citation:
PMID:  17521469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hop-derived food supplements and beers contain the prenylflavonoids xanthohumol (X), isoxanthohumol (IX) and the very potent phyto-oestrogen (plant-derived oestrogen mimic) 8-prenylnaringenin (8-PN). The weakly oestrogenic IX can be bioactivated via O-demethylation to 8-PN. Since IX usually predominates over 8-PN, human subjects may be exposed to increased doses of 8-PN. A dietary intervention trial with fifty healthy post-menopausal Caucasian women was undertaken. After a 4 d washout period, participants delivered faeces, blank urine and breath samples. Next, they started a 5 d treatment with hop-based supplements that were administered three times per d and on the last day, a 24 h urine sample was collected. A semi-quantitative FFQ was used to estimate fat, fibre, alcohol, caffeine and theobromine intakes. The recoveries of IX, 8-PN and X in the urine were low and considerable inter-individual variations were observed. A five-fold increase in the dosage of IX without change in 8-PN concentration resulted in a significant lower IX recovery and a higher 8-PN recovery. Classification of the subjects into poor (60%), moderate (25%) and strong (15%) 8-PN producers based on either urinary excretion or microbial bioactivation capacity gave comparable results. Recent antibiotic therapy seemed to affect the 8-PN production negatively. A positive trend between methane excretion and 8-PN production was observed. Strong 8-PN producers consumed less alcohol and had a higher theobromine intake. From this study we conclude that in vivo O-demethylation of IX increases the oestrogenic potency of hop-derived products.
Authors:
Selin Bolca; Sam Possemiers; Veerle Maervoet; Inge Huybrechts; Arne Heyerick; Stefaan Vervarcke; Herman Depypere; Denis De Keukeleire; Marc Bracke; Stefaan De Henauw; Willy Verstraete; Tom Van de Wiele
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-23
Journal Detail:
Title:  The British journal of nutrition     Volume:  98     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-11     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  950-9     Citation Subset:  IM    
Affiliation:
Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Bacterial Agents / pharmacology
Diet
Dietary Supplements*
Feces / chemistry,  microbiology
Female
Flavanones / biosynthesis*,  urine
Gastrointestinal Tract / microbiology
Humans
Humulus*
Methane / biosynthesis
Middle Aged
Phenotype
Phytoestrogens / metabolism
Postmenopause / physiology*
Propiophenones / urine
Xanthones / urine
Chemical
Reg. No./Substance:
0/8-prenylnaringenin; 0/Anti-Bacterial Agents; 0/Flavanones; 0/Phytoestrogens; 0/Propiophenones; 0/Xanthones; 0/isoxanthohumol; 6754-58-1/xanthohumol; 74-82-8/Methane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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