Document Detail

Microbial contamination of enteral feeding formulas and diarrhea.
MedLine Citation:
PMID:  10978850     Owner:  NLM     Status:  MEDLINE    
Twenty-five medical and surgical patients receiving liquid ready-to-use sterile enteral formulas were evaluated prospectively to investigate the relation of diarrhea to serum albumin level, total lymphocyte count, delayed hypersensitivity to purified protein derivative, antibiotic therapy, administration rate and site of enteral formula, and microbial contamination of enteral feeds. Formulas were administered to 6 patients with hang times of up to 6 h by pump-assisted continuous drip and to 19 patients with hang times of up to 3 h as a bolus feeding. Samples of formulas for microbial culture were obtained aseptically before and after feeding on the first and eighth day of the study period. The incidence of microbial contamination of the formula before and after feeding was 1 of 49 samples (2.0%) and 10 of 48 samples (20.8%), respectively. There were 2 patients with diarrhea, which occurred on the second day. Formula samples from 2 patients (100%) with diarrhea and 2 samples from 23 patients (8.7%) without diarrhea were contaminated with 10(4) cfu/mL or more, respectively. A significant difference (P = 0.04) was detected between the two groups. The other factors studied showed no significant association with the incidence of diarrhea. In conclusion, contaminated formula appears to play a significant role in the etiology of diarrhea in patients receiving enteral feeding.
T Okuma; M Nakamura; H Totake; Y Fukunaga
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  16     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-12     Completed Date:  2000-10-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  719-22     Citation Subset:  IM    
Department of Surgery and Clinical Laboratory, Izumi City Hospital, Kagoshima, Japan.
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MeSH Terms
Acinetobacter / isolation & purification
Aged, 80 and over
Diarrhea / microbiology*
Enteral Nutrition*
Food Microbiology*
Food, Formulated / microbiology*
Klebsiella pneumoniae / isolation & purification
Middle Aged
Reg. No./Substance:

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