Document Detail


Microbial causes of neonatal conjunctivitis.
MedLine Citation:
PMID:  6502299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the microbial causes of neonatal conjunctivitis by comparing 55 infants with purulent conjunctivitis and 60 healthy control infants. A mean of greater than 5 leukocytes per 1000X microscopic field was seen in Gram-stained smears obtained from the more inflamed eye in 77% of 30 untreated patients but none of 57 controls. Pathogens isolated more often from untreated patients than from controls included Haemophilus spp. (17% vs 2%, P = 0.01), Staphylococcus aureus (17% vs 2%, P = 0.01), Chlamydia trachomatis (14% vs 0%, P = 0.01), enterococci (8% vs 0%, P = 0.05), and Streptococcus pneumoniae (11% vs 2%, P = 0.06). One or more of these pathogens were isolated from the conjunctivae in 58% of patients and 5% of controls (P less than 0.001). Bacterial morphology seen on smear correlated with the pathogens cultured. Isolation of Haemophilus spp. or S. pneumoniae was associated with dacryostenosis. We conclude that several microbial pathogens are implicated in neonatal conjunctivitis. These organisms have differing susceptibilities to antimicrobial agents, so culture and sensitivity testing are required as a guide to therapy.
Authors:
K I Sandström; T A Bell; J W Chandler; C C Kuo; S P Wang; J T Grayston; H M Foy; W E Stamm; M K Cooney; A L Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  105     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-27     Completed Date:  1984-12-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  706-11     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Bacterial Infections*
Chlamydia trachomatis / isolation & purification
Conjunctivitis / etiology*,  microbiology
Conjunctivitis, Inclusion / diagnosis,  etiology
Exudates and Transudates / microbiology
Haemophilus Infections
Humans
Infant, Newborn
Lacrimal Duct Obstruction / etiology
Leukocyte Count
Pneumococcal Infections
Staphylococcal Infections
Grant Support
ID/Acronym/Agency:
AI 12192/AI/NIAID NIH HHS; AI 16222/AI/NIAID NIH HHS; AI 18186/AI/NIAID NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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