Document Detail

Microbial biotransformations of bile acids as detected by electrospray mass spectrometry.
MedLine Citation:
PMID:  23319120     Owner:  NLM     Status:  MEDLINE    
Many current experiments investigating the effects of diet, dietary supplements, and pre- and probiotics on the intestinal environments do not take into consideration the potential for using bile salts as markers of environmental change. Intestinal bacteria in vertebrates can metabolize bile acids into a number of different structures, with deamidation, hydroxyl group oxidation, and hydroxyl group elimination. Fecal bile acids are readily available to sample and contain a considerable structural complexity that directly relates to intestinal morphology, bile acid residence time in the intestine, and the species of microbial forms in the intestinal tract. Here we offer a classification scheme that can serve as an initial guide to interpret the different bile acid patterns expressed in vertebrate feces.
Lee R Hagey; Matthew D Krasowski
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Advances in nutrition (Bethesda, Md.)     Volume:  4     ISSN:  2156-5376     ISO Abbreviation:  Adv Nutr     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-15     Completed Date:  2013-06-28     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101540874     Medline TA:  Adv Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
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MeSH Terms
Bile Acids and Salts / analysis*,  metabolism*
Dietary Supplements*
Feces / chemistry
Intestines / metabolism,  microbiology
Mass Spectrometry / methods*
Reg. No./Substance:
0/Bile Acids and Salts

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