Document Detail

Microbial asymmetric oxidation of 2-butyl-1,3-propanediol.
MedLine Citation:
PMID:  17453192     Owner:  NLM     Status:  MEDLINE    
Microbial asymmetric oxidation of 2-butyl-1,3-propanediol was investigated for an efficient synthesis of S- and R-enantiomers of 2-hydroxymethylhexanoic acid (2-HMHA). From an intensive survey of the stocked bacterial strains, Acetobacter pasteurianus IAM 12073 and Pseudomonas putida IFO 3738 were found to show the highest S- and R-2-HMHA-producing activity, respectively. Under optimized conditions, A. pasteurianus (351 mg dry cell weight) and P. putida (642 mg dry cell weight) cells produced 12.0 g l(-1) S-2-HMHA with 89% enantiomeric excess (e.e.) at 24 h of incubation and 5.1 g l(-1) R-2-HMHA with 94% e.e. at 35 h of incubation from 2-butyl-1,3-propanediol.
K Mitsukura; T Uno; T Yoshida; T Nagasawa
Publication Detail:
Type:  Journal Article     Date:  2007-04-24
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  76     ISSN:  0175-7598     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  61-5     Citation Subset:  IM    
Department of Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
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MeSH Terms
Acetobacter / metabolism*
Propylene Glycol / metabolism*
Pseudomonas putida / metabolism*
Reg. No./Substance:
57-55-6/Propylene Glycol

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