| Microbes, intestinal inflammation and probiotics. | |
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MedLine Citation:
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PMID: 22149584 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Inflammatory bowel disease (IBD) is known for causing disturbed homeostatic balance among the intestinal immune compartment, epithelium and microbiota. Owing to the emergence of IBD as a major cause of morbidity and mortality, great efforts have been put into understanding the sequence of intestinal inflammatory events. Intestinal macrophages and dendritic cells act in a synergistic fashion with intestinal epithelial cells and microbiota to initiate the triad that governs the intestinal immune responses (whether inflammatory or regulatory). In this review, we will discuss the interplay of intestinal epithelial cells, bacteria and the innate immune component. Moreover, whether or not genetic intervention of probiotic bacteria is a valid approach for attenuating/mitigating exaggerated inflammation and IBD will also be discussed. |
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Authors:
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Mohammad W Khan; Amod A Kale; Praveen Bere; Sriharsha Vajjala; Elias Gounaris; Krishna Chaitanya Pakanati |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of gastroenterology & hepatology Volume: 6 ISSN: 1747-4132 ISO Abbreviation: Expert Rev Gastroenterol Hepatol Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278199 Medline TA: Expert Rev Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 81-94 Citation Subset: IM |
Affiliation:
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The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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