| Succession of microbial consortia in the developing infant gut microbiome. | |
| | |
MedLine Citation:
|
PMID: 20668239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The colonization process of the infant gut microbiome has been called chaotic, but this view could reflect insufficient documentation of the factors affecting the microbiome. We performed a 2.5-y case study of the assembly of the human infant gut microbiome, to relate life events to microbiome composition and function. Sixty fecal samples were collected from a healthy infant along with a diary of diet and health status. Analysis of >300,000 16S rRNA genes indicated that the phylogenetic diversity of the microbiome increased gradually over time and that changes in community composition conformed to a smooth temporal gradient. In contrast, major taxonomic groups showed abrupt shifts in abundance corresponding to changes in diet or health. Community assembly was nonrandom: we observed discrete steps of bacterial succession punctuated by life events. Furthermore, analysis of ≈ 500,000 DNA metagenomic reads from 12 fecal samples revealed that the earliest microbiome was enriched in genes facilitating lactate utilization, and that functional genes involved in plant polysaccharide metabolism were present before the introduction of solid food, priming the infant gut for an adult diet. However, ingestion of table foods caused a sustained increase in the abundance of Bacteroidetes, elevated fecal short chain fatty acid levels, enrichment of genes associated with carbohydrate utilization, vitamin biosynthesis, and xenobiotic degradation, and a more stable community composition, all of which are characteristic of the adult microbiome. This study revealed that seemingly chaotic shifts in the microbiome are associated with life events; however, additional experiments ought to be conducted to assess how different infants respond to similar life events. |
| | |
Authors:
|
Jeremy E Koenig; Aymé Spor; Nicholas Scalfone; Ashwana D Fricker; Jesse Stombaugh; Rob Knight; Largus T Angenent; Ruth E Ley |
Related Documents
:
|
23177349 - Learning about sounds contributes to learning about words: effects of prosody and phono... 16617839 - Infants' perception of depth from cast shadows. 11050219 - A new view of language acquisition. 17667409 - Facial attractiveness: visual impact of symmetry increases significantly towards the mi... 15769189 - Unwilling versus unable: infants' understanding of intentional action. 19945169 - Development of proximal arm muscle control during reaching in young infants: from varia... 23599119 - Probiotic administration in congenital heart disease: a pilot study. 9213229 - Primitive reflexes and early motor development. 7671549 - Inflammatory mediators and neonatal sepsis. rarely has so little been known by so many ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-07-28 |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 108 Suppl 1 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-03-16 Completed Date: 2011-05-17 Revised Date: 2012-04-26 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
|
Languages: eng Pagination: 4578-85 Citation Subset: IM |
Affiliation:
|
Department of Microbiology, Cornell University, Ithaca, NY 14853, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Base Sequence Cluster Analysis DNA Barcoding, Taxonomic DNA Primers / genetics Feces / microbiology Gastrointestinal Tract / microbiology* Humans Infant Infant, Newborn Metagenome / genetics* Molecular Sequence Data RNA, Ribosomal, 16S / genetics Sequence Analysis, DNA Species Specificity |
| Chemical | |
Reg. No./Substance:
|
0/DNA Primers; 0/RNA, Ribosomal, 16S |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-select...
Next Document: Dynamic antibody responses to the Mycobacterium tuberculosis proteome.