| Microaspiration in infants with laryngomalacia. | |
| | |
MedLine Citation:
|
PMID: 15475788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES/HYPOTHESIS: Laryngomalacia is the most common congenital laryngeal anomaly and the most frequent cause of stridor in infants. Infants with laryngomalacia may have associated respiratory symptoms other than stridor. In this study, we evaluated whether infants with laryngomalacia have episodes of microaspiration by calculating the amount of lipids present in the alveolar macrophages. STUDY DESIGN: We reviewed bronchoalveolar lavage (BAL) findings obtained in 14 infants with laryngomalacia and in 11 control children. METHODS: BAL was performed during flexible fiberoptic bronchoscopy (FFB) to diagnose persistent stridor. The presence of microaspiration was determined by evaluating the amount of lipid per single macrophage, assigning each cell a score from 0 to 4 according to the amount of lipid in the cytoplasm. RESULTS: The lipid-laden macrophage index was similar in patients and controls (31.5, range 12-177 vs. 45, range 35-106). In 5 of the 14 (36%) patients the index exceeded 100, and more than 25% of the cells were graded 3 and 4, indicating the presence of microaspiration. The lipid-laden macrophage index correlated significantly with the number and percentage of BAL neutrophils (Pearson correlation test, r = 0.83, P < .001 and r = 0.925, P < .001) as a marker of lung inflammation. CONCLUSIONS: Infants with laryngomalacia may have episodes of microaspiration. BAL performed during FFB to evaluate stridor may add helpful therapeutic information without increasing the risks of the procedure. |
| | |
Authors:
|
Fabio Midulla; Roberto Guidi; Giancarlo Tancredi; Serena Quattrucci; Felix Ratjen; Sergio Bottero; Katia Vestiti; Paola Francalanci; Renato Cutrera |
Related Documents
:
|
12359818 - Patterns of colonization with ureaplasma urealyticum during neonatal intensive care uni... 16522718 - Developmental regulation of the lung in preparation for life after birth: hormonal and ... 15018448 - Amniotic sac infection syndrome features fetal lung neuroendocrine cell hyperfunction. 11060558 - Respiratory problems in the adolescent with developmental delay. 17338838 - Aortic morphometry and microcephaly in hypoplastic left heart syndrome. 6449868 - Effects of early home environment on the mental development of down syndrome infants. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Laryngoscope Volume: 114 ISSN: 0023-852X ISO Abbreviation: Laryngoscope Publication Date: 2004 Sep |
Date Detail:
|
Created Date: 2004-10-11 Completed Date: 2004-10-22 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: United States |
Other Details:
|
Languages: eng Pagination: 1592-6 Citation Subset: IM |
Affiliation:
|
Servizio Speciale Fibrosi Cistica, Istituto di Clinica Pediatrica, Università di Roma La Sapienza, Italy. midulla@uniroma1.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bronchoalveolar Lavage Fluid Bronchoscopy Female Humans Infant Laryngeal Diseases / complications, congenital*, diagnosis Larynx / abnormalities* Lipids / analysis Macrophages, Alveolar / chemistry Male Pneumonia, Aspiration / diagnosis, etiology* Reference Values Respiratory Sounds / etiology* Statistics as Topic |
| Chemical | |
Reg. No./Substance:
|
0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Voice changes after androgen therapy for hypogonadotrophic hypogonadism.
Next Document: Viscoelastic properties of three vocal-fold injectable biomaterials at low audio frequencies.