Document Detail


Microarray-guided discovery of two-photon (2P) small molecule probes for live-cell imaging of cysteinyl cathepsin activities.
MedLine Citation:
PMID:  22711056     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A microarray immobilized with 105 aldehyde-containing small molecules was screened against mammalian cell lysates over-expressing cathepsin L to identify two potent inhibitors, which were subsequently converted into cell-permeable probes capable of live-cell imaging of endogenous cysteinyl cathepsin activities by two-photon fluorescence microscopy.
Authors:
Zhenkun Na; Lin Li; Mahesh Uttamchandani; Shao Q Yao
Related Documents :
22630166 - A cell-penetrating ratiometric nanoprobe for intracellular chloride.
21082286 - De novo emerged stemness signatures in epithelial monolayers developed from extirpated ...
789096 - A plaque assay for all cells secreting ig of a given type or class.
11323016 - Matrix metalloproteinase deficiencies do not impair cell-associated fibrinolytic activity.
1327926 - Mutated insulin receptor val996 reduces insulin-dependent generation of inositol glycan...
24173716 - Persistent telomere cohesion triggers a prolonged anaphase.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-18
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore. chmyaosq@nus.edu.sg.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Standard Protocol for Indications, Methodology, and Interpretation of Combined Esophageal Impedance-...
Next Document:  Microfluidic electronics.