| Microarray-guided discovery of two-photon (2P) small molecule probes for live-cell imaging of cysteinyl cathepsin activities. | |
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MedLine Citation:
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PMID: 22711056 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A microarray immobilized with 105 aldehyde-containing small molecules was screened against mammalian cell lysates over-expressing cathepsin L to identify two potent inhibitors, which were subsequently converted into cell-permeable probes capable of live-cell imaging of endogenous cysteinyl cathepsin activities by two-photon fluorescence microscopy. |
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Authors:
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Zhenkun Na; Lin Li; Mahesh Uttamchandani; Shao Q Yao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-18 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: - ISSN: 1364-548X ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore. chmyaosq@nus.edu.sg. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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