Document Detail

Microangiopathy of split-skin grafts in venous ulcers.
MedLine Citation:
PMID:  15008869     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In patients with chronic venous insufficiency, microangiopathy of blood and lymph capillaries caused by venous hypertension plays a major role in the development of venous ulceration. Conservative treatment of venous leg ulcers often fails, and split-skin grafting is sometimes performed. OBJECTIVE: To evaluate the microcirculation and especially the regeneration and function of lymphatic vessels in skin grafts in patients with chronic venous insufficiency. METHODS: The microcirculation of 15 split-skin grafts was studied by fluorescence microlymphography and measurement of transcutaneous oxygen tension (tcpO2) in 13 patients. RESULTS: The mean age of the skin grafts was 70.9 months. In only two skin grafts were a few intact lymph meshes found. In all other cases, only fragments of lymphatic capillaries have been detected. In seven skin grafts, cutaneous backflow of dye through insufficient deeper lymph channels was observed. The maximal spread of the dye in the lymphatic network was increased in the skin grafts (17.6 +/- 22.9 mm). The mean value of tcpO2 was only 27.1 +/- 18.1 mm Hg. CONCLUSIONS: In split-skin grafts of patients with venous ulcers, severe microcirculatory changes are present and characterized by hypoxia and abnormal regeneration and function of lymphatic vessels.
Beatrice R Amann-Vesti; Corinne Ruesch; Gabriele Gitzelmann; Juerg Hafner; Renate Koppensteiner
Related Documents :
23812179 - Cocaine-induced vasoconstriction in the human coronary microcirculation: new evidence f...
4036489 - Thromboendarterectomy vs. aortic bifurcation graft for unilateral iliac artery atherosc...
1091039 - Cardiac heterotransplantation. morphological and immunohistological studies.
8223739 - Assessment of the influence of spinal cord stimulation on left ventricular function in ...
25020589 - P170peripheral and coronary vasodilator response in chronic weary heart.
24244389 - Exogenous administration of a recombinant variant of tweak impairs healing after myocar...
22269099 - Resuscitation of non-postcardiotomy cardiogenic shock or cardiac arrest with extracorpo...
16258779 - Hypereosinophilic syndrome associated with acute necrotizing myocarditis and cardiomyop...
6940649 - Sudden cardiac death following adriamycin therapy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  30     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-10     Completed Date:  2004-06-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-402     Citation Subset:  IM    
Department of Internal Medicine, Division of Angiology, University Hospital, Zurich, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Middle Aged
Peripheral Vascular Diseases / etiology*
Postoperative Complications / etiology*
Skin Transplantation* / methods
Varicose Ulcer / surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  EMLA and ear surgery: is it possible to achieve full-thickness anesthesia with EMLA?
Next Document:  Immunostaining melanoma frozen sections: the 1-hour protocol.