| Microalbuminuria versus brain natriuretic peptide in cardiac hypertrophy of hypertensive rats. | |
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MedLine Citation:
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PMID: 20533867 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The objective of this study was to assess a possible link between microalbuminuria (MA), a major risk factor of the cardiorenal syndrome and the brain natriuretic peptide (BNP), a marker of cardiac hypertrophy. Two kidney-one clip (2K-1C) renovascular hypertension was induced in 24 male Wistar rats (weighing 220-250 g). Rats were randomized into four groups for 8 weeks: Sham, not treated; Bos, treated with bosentan; Cap, treated with captopril; Bos/Cap, treated with both drugs. Blood pressure, plasma BNP and transforming growth factor beta1 (TGF-beta1) concentrations, microalbuminuria and creatininemia as well as cardiac mass, BNP, alpha- and beta-myosin heavy chain (MHC) gene expression and kidney histology were determined. Following stenosis, Sham rats developed hypertension (p<0.001), an increase in BNP (p<0.05) and TGF-beta1 (p<0.005) concentrations, creatinine levels (p<0.001), and urinary albumin (p<0.001). Under drug treatment, decreases in blood pressure (p<0.001), creatinine levels (p<0.05), plasma TGF-beta1 (p<0.005) and BNP (p<0.05) concentrations, were concomitant with the absence of MA which was significantly correlated with reductions in cardiac mass (p<0.05) and hypertrophy markers (BNP and beta-MHC gene expression) (p<0.005) as well as in renal fibrosis. These findings suggest a potential link between microalbuminuria evolution and BNP as well as a possible effect of microalbuminuria-lowering therapy on halting the progression, or even inducing the regression of cardiac hypertrophy. |
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Authors:
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Y Saliba; E Chouery; A Mégarbané; H Jabbour; N Fares |
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Publication Detail:
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Type: Journal Article Date: 2010-06-09 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 59 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2010 |
Date Detail:
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Created Date: 2011-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 871-80 Citation Subset: IM |
Affiliation:
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Laboratoire de Physiologie et Physiopathologie, Faculté de Médecine, Université Saint Joseph, Beyrouth, Liban. nassim.fares@usj.edu.lb. |
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