Document Detail

Microalbuminuria and other cardiovascular risk factors in nondiabetic subjects.
MedLine Citation:
PMID:  1468818     Owner:  NLM     Status:  MEDLINE    
The association between urinary albumin:creatinine ratio and other cardiovascular risk factors such as age, blood pressure, obesity, glycemic indices, insulin and lipid profile was examined in a population in a Chinese community consisting of 795 men (mean age 35.8 +/- 8.8 yr) and 538 women (mean age 37.9 +/- 8.9 yr) with a normal glucose tolerance defined by WHO criteria. Men with a urinary albumin:creatinine ratio above the 90th percentile had higher systolic and diastolic blood pressures, fasting plasma glucose, 2-h glucose after a 75 g oral glucose load, and fasting serum insulin. Women with high urinary albumin:creatinine values had higher systolic and diastolic blood pressures, body mass index, waist-hip ratio, fasting insulin and triglycerides. Multivariate analysis showed that only systolic blood pressure and fasting glucose in men, and diastolic blood pressure and fasting insulin in women, independently contributed to urinary albumin:creatinine. When the effect of blood pressure was eliminated by excluding subjects with systolic blood pressure > 140 and diastolic > 90 mm Hg, only fasting insulin was associated with urinary albumin:creatinine in women. No associations were found for men. We conclude that microalbuminuria may be a marker for cardiovascular disease only because of its association with blood pressure in men, while in women, there is an additional independent association with fasting serum insulin.
J Woo; C S Cockram; R Swaminathan; E Lau; A Chan; R Cheung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  37     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-01-26     Completed Date:  1993-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  345-50     Citation Subset:  IM    
Department of Medicine, Chinese University of Hong Kong.
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MeSH Terms
Age Factors
Albuminuria / complications*,  urine
Blood Glucose / analysis
Body Mass Index
Cardiovascular Diseases / epidemiology*,  etiology
China / ethnology
Cholesterol / blood
Creatinine / urine
Evaluation Studies as Topic
Hong Kong / epidemiology
Hypertension / complications,  diagnosis
Insulin / blood
Middle Aged
Multivariate Analysis
Obesity / complications,  diagnosis
Predictive Value of Tests
Risk Factors
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 57-88-5/Cholesterol; 60-27-5/Creatinine

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