Document Detail


Microalbuminuria in Non-Diabetic Stemi : An Independent Predictor for Acute Kidney Injury.
MedLine Citation:
PMID:  22694718     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Aims: To assess the impact of microalbuminuria on the development of acute kidney injury and to investigate its prognostic role at long term follow-up in 526 consecutive patients with ST elevation myocardial infarction without previously known diabetes. Methods: Microalbuminuria was measured using immunonephelemetry in the urine collected in the night Main Results: Patients with microalbuminuria were older (p= 0.013). They showed higher values of peak glycemia (p=0.017), peak Tn I (p<0.001), NT-pro BNP (p=0.020), ESR (p=0.003), CRP (p=0.020) and leukocyte count (p<0.001). Lower eGFR were observed in patients with microalbuminuria both on admission and during ICCU stay (p=0.048 and p=0.003, respectively). A positive correlation was observed between CRP and microalbuminuria (Spearman's rho 0.114, p=0.024).The composite end point was observed in seventy three patients (18 patients died and 59 pts developed acute kidney injury) At multivariable regression analysis microalbuminuria was an independent predictor of acute kidney injury. At follow-up [42.6 (25(th)-75(th) percentile 17.5 - 56.8) months], Kaplan-Meier curve analysis showed that patients with microalbuminuria had a lower survival rate in respect to patients without microalbuminuria. Cox regression analysis documented that microalbuminuria was an independent predictor of long term mortality (HR: 1.089; 97%CI 1.036 - 1.145; p<0.001) Conclusions: in a large series of STEMI patients without previously known diabetes submitted to PCI, microalbuminuria, as a marker of endothelial permeability following higher systemic inflammatory activation and larger infarct lesions, is an independent predictor for the development acute kidney injury. Furthermore, microalbuminuria identifies a subset of patients at higher risk for long term mortality.
Authors:
Chiara Lazzeri; Serafina Valente; Marco Chiostri; Claudio Picariello; Paola Attanà; Gian Franco Gensini
Related Documents :
22820478 - Regular coffee but not espresso drinking is protective against fibrosis in a cohort mai...
22811098 - 109 radiographic and clinical follow-up of syringomyelia in patients treated for tether...
22082878 - Absolute blood eosinophil count and 1-year mortality risk following hospitalization wit...
21833008 - Risk factors of erectile dysfunction and penile vascular changes after surgical repair ...
19602788 - Inflammatory cells in lung disease associated with rheumatoid arthritis.
8492948 - Neurocognitive dysfunction in the eosinophilia-myalgia syndrome.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-14
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  -     ISSN:  1651-2006     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  HIV, aging, and advance care planning: are we successfully planning for the future?
Next Document:  Ancient origin of the divergent forms of leucyl-tRNA synthetases in the Halobacteriales.