Document Detail


Microalbuminuria and endothelial dysfunction in essential hypertension.
MedLine Citation:
PMID:  7912295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microalbuminuria (urinary albumin excretion between 20 and 200 micrograms/min) and endothelial dysfunction coexist in patients with essential hypertension. To evaluate whether the two phenomena are related and the determinants of that association, we recruited 10 untreated males with essential hypertension and microalbuminuria without diabetes to be compared with an equal number of matched patients with essential hypertension excreting albumin in normal amounts and 10 normal controls. The status of endothelial function was inferred from circulating von Willebrand Factor antigen (vWF), a glycoprotein secreted in greater amounts when the vascular endothelium is damaged. vWF concentrations were higher in hypertensive patients with microalbuminuria than in hypertensive patients without and controls. Individual vWF and urine albumin-excretion values were correlated (r = 0.55, p < 0.002). Blood pressure correlated with both urinary albumin excretion and vWF. Left ventricular mass index and minimal forearm vascular resistances were comparable in patients with hypertension and higher than in controls; total and low-density lipoprotein cholesterol, triglycerides, lipoprotein-a, Factor VII, and plasminogen activator inhibitor-1 did not differ. Fibrinogen was higher and creatinine clearance lower in microalbuminurics. Albuminuria in essential hypertension may reflect systemic dysfunction of the vascular endothelium, a structure intimately involved in permeability, haemostasis, fibrinolysis, and blood pressure control. This abnormality may have important physiopathological implications and expose these patients to increased cardiovascular risk.
Authors:
R Pedrinelli; O Giampietro; F Carmassi; E Melillo; G Dell'Omo; G Catapano; E Matteucci; L Talarico; M Morale; F De Negri
Related Documents :
2486875 - Hostile personality characteristics and prostaglandins in essential hypertension.
11185685 - Effects of doxazosin on hemorheological, hemodynamic and lipid parameters in patients w...
16303635 - Anti-proteinuric effect of an n-type calcium channel blocker, cilnidipine.
3539345 - An indirect approach for the study of the elastic modulus of the brachial artery in pat...
18699665 - Rocket-borne instrumentation using the resonant absorption technique to study the geoco...
6132785 - Pulmonary and systemic vascular effects of skf-82526-j, a new specific peripheral dopam...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  344     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-07-28     Completed Date:  1994-07-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  AIM; IM    
Affiliation:
Clinica Medica 1, University of Pisa, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Albuminuria*
Endothelium, Vascular / physiopathology*
Hemodynamics
Humans
Hypertension / blood,  physiopathology,  urine*
Lipids / blood
Male
Middle Aged
von Willebrand Factor / analysis
Chemical
Reg. No./Substance:
0/Lipids; 0/von Willebrand Factor
Comments/Corrections
Comment In:
Lancet. 1994 Aug 20;344(8921):549-50   [PMID:  7980788 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Expanding the physician care team: its effect on patient care, resident function, and education.
Next Document:  Double-blind trial of lignocaine versus sotalol for acute termination of spontaneous sustained ventr...