Document Detail

Microalbuminuria and endothelial dysfunction in essential hypertension.
MedLine Citation:
PMID:  7912295     Owner:  NLM     Status:  MEDLINE    
Microalbuminuria (urinary albumin excretion between 20 and 200 micrograms/min) and endothelial dysfunction coexist in patients with essential hypertension. To evaluate whether the two phenomena are related and the determinants of that association, we recruited 10 untreated males with essential hypertension and microalbuminuria without diabetes to be compared with an equal number of matched patients with essential hypertension excreting albumin in normal amounts and 10 normal controls. The status of endothelial function was inferred from circulating von Willebrand Factor antigen (vWF), a glycoprotein secreted in greater amounts when the vascular endothelium is damaged. vWF concentrations were higher in hypertensive patients with microalbuminuria than in hypertensive patients without and controls. Individual vWF and urine albumin-excretion values were correlated (r = 0.55, p < 0.002). Blood pressure correlated with both urinary albumin excretion and vWF. Left ventricular mass index and minimal forearm vascular resistances were comparable in patients with hypertension and higher than in controls; total and low-density lipoprotein cholesterol, triglycerides, lipoprotein-a, Factor VII, and plasminogen activator inhibitor-1 did not differ. Fibrinogen was higher and creatinine clearance lower in microalbuminurics. Albuminuria in essential hypertension may reflect systemic dysfunction of the vascular endothelium, a structure intimately involved in permeability, haemostasis, fibrinolysis, and blood pressure control. This abnormality may have important physiopathological implications and expose these patients to increased cardiovascular risk.
R Pedrinelli; O Giampietro; F Carmassi; E Melillo; G Dell'Omo; G Catapano; E Matteucci; L Talarico; M Morale; F De Negri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  344     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-07-28     Completed Date:  1994-07-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  AIM; IM    
Clinica Medica 1, University of Pisa, Italy.
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MeSH Terms
Endothelium, Vascular / physiopathology*
Hypertension / blood,  physiopathology,  urine*
Lipids / blood
Middle Aged
von Willebrand Factor / analysis
Reg. No./Substance:
0/Lipids; 0/von Willebrand Factor
Comment In:
Lancet. 1994 Aug 20;344(8921):549-50   [PMID:  7980788 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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