| Microalbuminuria is determined by systolic and pulse pressure over a 12-year period and related to peripheral artery disease in normotensive and hypertensive subjects: the Three Areas Study in Greece (TAS-GR). | |
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MedLine Citation:
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PMID: 16703191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microalbuminuria and peripheral artery disease represent 2 different forms of target organ damage due to raised blood pressure. The aim of this study was to investigate the association between blood pressure with microalbuminuria and the appearance of peripheral artery disease after more than a decade, and moreover, to address whether any relationship exists between microalbuminuria and peripheral disease in a Greek Caucasian population. In 1990, 635 normal subjects were examined and their blood pressure was recorded. Nine and 12 years later, subjects were reexamined and 361 of them (57%) were available at last visit for the determination of microalbuminuria and ankle-arm index. Microalbuminuria was detected in 35/361 (9.7%) and peripheral artery disease in 89/361 (24.7%). Both conditions were statistically correlated with pulse and systolic blood pressure at all time points during the 12-year follow-up period, while the relationship with diastolic and mean arterial pressure existed only for baseline values and was then abolished. Microalbuminuria was statistically correlated to peripheral artery disease (r = -0.460, p = 0.0001). Blood pressure levels seemed to predict the appearance of microalbuminuria and peripheral disease after 12 years. Microvasculature and macrovasculature abnormalities (microalbuminuria and peripheral disease, respectively) showed a significant relationship, suggesting a common pathogenetic mechanism. |
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Authors:
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Alexandros Tsakiris; Michael Doumas; Dimitrios Lagatouras; Grigorios Vyssoulis; Evangelia Karpanou; Nearchos Nearchou; Chrysoula Kouremenou; Panagiotis Skoufas |
Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: Angiology Volume: 57 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 2006 May-Jun |
Date Detail:
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Created Date: 2006-05-16 Completed Date: 2006-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 313-20 Citation Subset: IM |
Affiliation:
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Hypertension Outpatient Clinic, 1st Cardiologic Department, Hellenic Red Cross Hospital, Athens, Greece. a040144@otenet.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Albuminuria / etiology, physiopathology* Blood Pressure* Follow-Up Studies Greece Health Status Indicators Humans Hypertension / complications, physiopathology* Microcirculation Middle Aged Peripheral Vascular Diseases / complications, physiopathology* Pulse Systole Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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