| Microalbuminuria is associated with impaired arterial and venous endothelium-dependent vasodilation in patients with Type 2 diabetes. | |
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MedLine Citation:
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PMID: 20354354 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Microalbuminuria in Type 2 diabetes is associated with arterial endothelial dysfunction, but the venous bed was never evaluated. AIM: To study the endothelial function in the venous and arterial bed in patients with Type 2 diabetes with normoalbuminuria or microalbuminuria. MATERIAL AND METHODS: We evaluated 28 patients with Type 2 diabetes, glycated hemoglobin (HbA1c) <7.5%, who were classified as normo- (albuminuria <30 mg/24 h; no.=16) or microalbuminuric (albuminuria 30-300 mg/24 h; no.=12). Venous and arterial endothelial function were assessed by the dorsal hand vein technique (venodilation by acetylcholine) and brachial artery flow-mediated vasodilation, respectively. RESULTS: Patients were normotensive (systolic arterial pressure: 131.1±10.6 mmHg) and on good metabolic control (HbA1c: 6.6±0.6%). Microalbuminuric patients presented impaired venous (32.9±17.4 vs 59.3±26.5%; p=0.004) and arterial vasodilation (1.8±0.9 vs 5.1±2.4; p<0.001), as compared to normoalbuminuric patients. There was a negative correlation between acetylcholine-induced venodilation and albuminuria (r=-0.62; p<0.001) and HbA1c (r=-0.41; p=0.032). The same was observed between flowmediated arterial vasodilation and albuminuria (r=-0.49; p=0.007) and HbA1c (r=-0.44; p=0.019). Venous and arterial vasodilation was positively correlated (r=0.50; p=0.007). CONCLUSIONS: Both venous and arterial endothelial function are impaired in Type 2 microalbuminuric diabetics, in spite of good metabolic control, suggesting that other factors are involved in its pathogenesis. |
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Authors:
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A M V Silva; B D Schaan; L U Signori; R D M Plentz; H Moreno; M C Bertoluci; M C Irigoyen |
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Publication Detail:
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Type: Journal Article Date: 2010-03-30 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 33 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: 696-700 Citation Subset: IM |
Affiliation:
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Department of Physiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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