| Microalbuminuria and associated cardiovascular risk factors in the community. | |
| | |
MedLine Citation:
|
PMID: 1596306 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The prevalence of microalbuminuria and relationship to cardiovascular risk factors was examined in a cross-sectional community survey of cardiovascular risk factors. Microalbuminuria (when classified as albumin concentration greater than 20 micrograms/ml) was present in 6.3% of subjects but in conjunction with an albumin/creatinine ratio greater than 3.5 in only 2.2%. Diastolic blood pressure, prevalence of abnormal electrocardiographs, and to a lesser extent systolic blood pressure and fibrinogen concentration, were greater in those with albuminuria concentrations greater than 20 micrograms/ml. The strongest positive univariate correlates of albumin/creatinine ratios in those with detectable albuminuria were age, fibrinogen, blood pressure, total- and low density lipoprotein-(LDL) cholesterol, apo B and alcohol intake, whereas fasting insulin and insulin resistance were inversely correlated. Multiple regression analysis revealed that age, gender, systolic blood pressure and insulin resistance independently accounted for 37% of the variability in albumin/creatinine ratios. When those 10 subjects with microalbuminuria and albumin/creatinine ratios greater than 3.5 were matched with 20 with normoalbuminuria for age, gender and body mass index, the microalbuminuric subjects had significantly lower LDL cholesterol/apo B ratios and a tendency to lower high density lipoprotein (HDL) cholesterol and HDL cholesterol/apo A1 ratios. Microalbuminuria is uncommon in the general population, and is related to ageing, blood pressure and other vascular risk factors. It may reflect the presence of established cardiovascular disease. |
| | |
Authors:
|
P H Winocour; J O Harland; J P Millar; M F Laker; K G Alberti |
Related Documents
:
|
8068246 - Variations in serum levels of dolichol and its occurrence in human atherosclerotic plaq... 3107546 - Effect of prazosin and propranolol on lipoproteins of hypertensive patients. 10203116 - Measures of disease control in medicare beneficiaries with diabetes mellitus. 8507196 - Low density lipoprotein subfractions increase thromboxane formation in endothelial cells. 18445896 - Stabilizing effects of cool dialysate temperature on hemodynamic parameters in diabetic... 2603896 - The central hemodynamics of severe preeclampsia. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Atherosclerosis Volume: 93 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 1992 Mar |
Date Detail:
|
Created Date: 1992-07-01 Completed Date: 1992-07-01 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 71-81 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Medical School, University of Newcastle upon Tyne, U.K. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Aged Albuminuria* Cardiovascular Diseases / etiology, urine* Creatinine / blood Cross-Sectional Studies Diabetes Complications Female Humans Hypertension / complications Male Middle Aged Risk Factors Sex Factors |
| Chemical | |
Reg. No./Substance:
|
60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Essential phospholipids modify immunological functions and reduce experimental atherosclerosis in ra...
Next Document: The effect of bezafibrate on very low density lipoprotein (VLDL), intermediate density lipoprotein (...