| Microalbuminuria as a risk factor: the influence of renin-angiotensin system blockade. | |
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MedLine Citation:
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PMID: 20634721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microalbuminuria, the increase in urinary albumin excretion, has most often been linked with renal disease in diabetic patients. However, accumulating data demonstrate a link between albuminuria and cardiovascular disease in both diabetic and nondiabetic patients, even at very low levels of urinary albumin excretion once considered to be 'normal'. The reasons for the increase in cardiovascular risk may be linked to generalized vascular and endothelial dysfunction, mediated by the renin-angiotensin system and the angiotensin II type 1 receptor. Accordingly, angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers have demonstrated some success in treating microalbuminuria. With the prevalence of microalbuminuria at around 7% in the general population, and as high as 39% in diabetic patients, reducing and preventing microalbuminuria is becoming of increasing interest in helping to reduce cardiovascular risk. Subsequently, international guidelines have recommended screening for the presence of microalbuminuria in all patients with hypertension, diabetes or both. |
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Authors:
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Jan Menne; Christos Chatzikyrkou; Hermann Haller |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1983-94 Citation Subset: IM |
Affiliation:
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Medizinische Hochschule, Hannover, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albuminuria
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complications,
physiopathology*,
prevention & control Cardiovascular Diseases / epidemiology*, physiopathology Diabetes Complications / complications Endothelium, Vascular / physiopathology Humans Hypertension / complications Receptor, Angiotensin, Type 1 / physiology Renin-Angiotensin System / physiology* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Angiotensin, Type 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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