Document Detail

Microalbuminuria as a predictor of early glomerular injury in children with sickle cell disease.
MedLine Citation:
PMID:  12793307     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A cross sectional study was carried out to determine the prevalence of microalbuminuria in the pediatric patients with sickle cell disease. METHODS: The study was carried out on 64 pediatric patients aged less than 14 years with documented HbSS, HbAS and HbS beta thalassemia, Microalbuminuria was estimated using single radial immuno diffusion technique. Majority of the study subjects were of HbSS type. 38.5% had symptoms for > 2 years. 18.8% of the study population had significant microalbuminuria (19.2% of SS type and 18.8% of Hb AS types). RESULT: Microalbuminuria excretion was significantly more in patients > 9 years of age as compared to young patients (p < 0.05). Mean serum creatinine levels did not show any significant difference in the various study groups. CONCLUSION: Microalbuminuria estimation is a very important clinical marker of preclinical glomerular damage in patients with sickle cell disease. It estimation would help in the early detection of such patients and prompt initiation of therapy.
Vikram Datta; Janaki Raju Ayengar; Shilpaja Karpate; Pushpa Chaturvedi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  70     ISSN:  0019-5456     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-06-09     Completed Date:  2003-07-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  307-9     Citation Subset:  IM    
Department of Pediatrics, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra, India.
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MeSH Terms
Albuminuria / epidemiology*
Anemia, Sickle Cell / epidemiology*
Arterial Occlusive Diseases / epidemiology
Biological Markers / urine
Child, Preschool
Cross-Sectional Studies
Hemoglobins / analysis
Hospitalization / statistics & numerical data
India / epidemiology
Kidney Glomerulus / physiopathology
Leukocyte Count
Predictive Value of Tests
beta-Thalassemia / blood,  epidemiology*
Reg. No./Substance:
0/Biological Markers; 0/Hemoglobins

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