| Microalbuminuria as a predictor of early glomerular injury in children with sickle cell disease. | |
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MedLine Citation:
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PMID: 12793307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: A cross sectional study was carried out to determine the prevalence of microalbuminuria in the pediatric patients with sickle cell disease. METHODS: The study was carried out on 64 pediatric patients aged less than 14 years with documented HbSS, HbAS and HbS beta thalassemia, Microalbuminuria was estimated using single radial immuno diffusion technique. Majority of the study subjects were of HbSS type. 38.5% had symptoms for > 2 years. 18.8% of the study population had significant microalbuminuria (19.2% of SS type and 18.8% of Hb AS types). RESULT: Microalbuminuria excretion was significantly more in patients > 9 years of age as compared to young patients (p < 0.05). Mean serum creatinine levels did not show any significant difference in the various study groups. CONCLUSION: Microalbuminuria estimation is a very important clinical marker of preclinical glomerular damage in patients with sickle cell disease. It estimation would help in the early detection of such patients and prompt initiation of therapy. |
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Authors:
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Vikram Datta; Janaki Raju Ayengar; Shilpaja Karpate; Pushpa Chaturvedi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of pediatrics Volume: 70 ISSN: 0019-5456 ISO Abbreviation: Indian J Pediatr Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-06-09 Completed Date: 2003-07-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0417442 Medline TA: Indian J Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 307-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra, India. vikramdatta123@rediff.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Albuminuria / epidemiology* Anemia, Sickle Cell / epidemiology* Arterial Occlusive Diseases / epidemiology Biological Markers / urine Child Child, Preschool Comorbidity Cross-Sectional Studies Female Hemoglobins / analysis Hospitalization / statistics & numerical data Humans India / epidemiology Infant Kidney Glomerulus / physiopathology Leukocyte Count Male Predictive Value of Tests Prevalence beta-Thalassemia / blood, epidemiology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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