Document Detail

Microalbuminuria as a marker of silent myocardial ischaemia in IDDM patients.
MedLine Citation:
PMID:  8817111     Owner:  NLM     Status:  MEDLINE    
Insulin-dependent diabetic (IDDM) subjects with microalbuminuria have an increased long-term risk of overt cardiovascular disease; however, the early exposure to cardiovascular risk factors may increase their predisposition to current silent myocardial ischaemia. The frequency of silent myocardial ischaemia detected by stress echocardiography and electrocardiography was significantly greater in 32 asymptomatic IDDM patients with microalbuminuria compared to 32 normoalbuminuric IDDM patients (25% [n = 8] vs 6.3% [n = 2]; p = 0.03, odds ratio [95% CI] 6.3 [1.2, 37.8]). Elective coronary artery bypass grafting was required in 1 patient with microalbuminuria and silent myocardial disease. Microalbuminuria and poorer autonomic function were independently associated with silent myocardial ischaemia in multivariate analysis (p = 0.03 and p = 0.02, respectively). Screening for silent myocardial ischaemia using these non-invasive tests may be warranted in microalbuminuric IDDM which patients could be of considerable clinical importance.
K A Earle; M Mishra; A Morocutti; D Barnes; E Stephens; J Chambers; G C Viberti
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetologia     Volume:  39     ISSN:  0012-186X     ISO Abbreviation:  Diabetologia     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-17     Completed Date:  1996-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  854-6     Citation Subset:  IM    
Department of Diabetes and Endocrinology, UMDS, London, UK.
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MeSH Terms
Biological Markers / analysis,  urine
Cohort Studies
Diabetes Mellitus, Type 1 / complications*,  urine
Middle Aged
Myocardial Ischemia / diagnosis,  prevention & control*
Odds Ratio
Risk Factors
Reg. No./Substance:
0/Biological Markers

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