Document Detail

MicroRNAs regulate both epithelial-to-mesenchymal transition and cancer stem cells.
MedLine Citation:
PMID:  23455327     Owner:  NLM     Status:  Publisher    
Concepts and experimental models derived from basic research have been successfully applied to the field of molecular oncology, tremendously increasing our knowledge of the nature and the progression of tumors. The process of epithelial-to-mesenchymal transition, the cancer stem cell hypothesis, and their functional association and interdependence represent some of the most significant examples. The molecular determinants underlying the plasticity of cancers are currently the object of extensive research efforts, and a substantial body of evidence suggests that these models can be connected by the regulatory role of microRNAs, small noncoding RNA molecules with a fundamental role in many cellular functions. This review will highlight and discuss this link and its possible implications for the fight against cancer.Oncogene advance online publication, 4 March 2013; doi:10.1038/onc.2013.55.
P Ceppi; M E Peter
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-04
Journal Detail:
Title:  Oncogene     Volume:  -     ISSN:  1476-5594     ISO Abbreviation:  Oncogene     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
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