Document Detail


MicroRNAs: a new therapeutic frontier for muscle wasting in chronic kidney disease.
MedLine Citation:
PMID:  22846810     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Multiple microRNAs (miRs) are implicated in muscle cell differentiation and muscle mass regulation. Pharmacological agents targeting miR-486 and other miRs, involved in muscle mass regulation, could potentially be developed into therapeutic agents for muscle wasting. Muscle wasting is prevalent among patients with chronic kidney disease (CKD). Xu et al. showed that miR-486 mimetic ameliorated muscle wasting in mice with CKD. miR mimetics may represent a new therapeutic frontier for muscle wasting in CKD.
Authors:
Robert H Mak; Wai W Cheung
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  82     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  373-4     Citation Subset:  IM    
Affiliation:
Division of Pediatric Nephrology, University of California, San Diego, Rady Children's Hospital, San Diego, California, USA.
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