Document Detail


MicroRNAs in the regeneration of skeletal muscle.
MedLine Citation:
PMID:  23276946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MicroRNAs (miRNAs) have emerged as critical regulators of numerous biological processes by modulating gene expression at the post-transcriptional level. The discovery of miRNAs as new and important regulators of gene expression is expected to broaden our biological understanding of the regulatory mechanism in muscle by adding another dimension of regulation to the diversity and complexity of gene-regulatory networks. Exercise-induced skeletal muscle injury and repair have always been among the highlights of research in sports medicine. However, many mechanism problems that occur during regeneration and repair in the aftermath of skeletal muscle injury remain unsolved. It has become increasingly clear that the regeneration of skeletal muscle development involve regulation by miRNAs. In the last few years the field has seen a rapid expansion of our knowledge of miRNAs in the regeneration of skeletal muscle. This study reviews the miRNAs related with regeneration of skeletal muscle, and discuss the regulation of their expression in muscles, and emerging themes of miRNA regulation.
Authors:
Xinkai Yu; Qun Zuo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  608-15     Citation Subset:  IM    
Affiliation:
Shanghai University of Sport, Shanghai, 200438, China. yxinkai@yeah.net
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Mice
MicroRNAs / physiology*
Muscle Development / genetics,  physiology*
Muscle, Skeletal / physiology
MyoD Protein / genetics
PAX7 Transcription Factor / genetics
Regeneration / genetics*
Satellite Cells, Skeletal Muscle / physiology*
Signal Transduction / drug effects
Chemical
Reg. No./Substance:
0/MIRN206 microRNA, human; 0/MicroRNAs; 0/Mirn206 microRNA, mouse; 0/MyoD Protein; 0/PAX7 Transcription Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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