Document Detail


MicroRNAs in pregnancy.
MedLine Citation:
PMID:  21353310     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since the discovery of non-coding RNAs, several families of small regulatory molecules have been described including small nucleolar RNAs, piwi-interacting RNAs and microRNAs (miRNAs). MiRNAs are small single-stranded RNA molecules which play an important role in the regulation of gene expression at the transcriptional level. Recent studies demonstrated that about 30% of human genes are regulated by miRNAs and their deregulation has been associated with malignancies and poor outcome. Therefore, it is not surprising that profiling of miRNAs expression and studies on their regulation became a great field of interest in the last decade. However, miRNA-mediated regulation in pregnancy remains poorly investigated although several independent processes associated with placenta development have been shown to be miRNA-regulated. This review provides a general overview of the current data on profiles and functions of microRNAs in the peri-implantation period, embryonic stem cells, placentation and pregnancy, as well as in several pregnancy-related pathologies. We conclude that miRNAs present in the maternal circulation may provide a new promising diagnostic tool for pregnancy disorders.
Authors:
Diana M Morales Prieto; Udo R Markert
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-02-25
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  88     ISSN:  1872-7603     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-07-18     Revised Date:  2012-01-25    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  106-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Klinik für Frauenheilkunde und Geburtshilfe, Abteilung für Geburtshilfe, Placenta-Labor, Friedrich-Schiller-Universität Jena, Bachstr. 18, 07743 Jena, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryonic Stem Cells / cytology,  metabolism*
Female
Humans
MicroRNAs / genetics,  metabolism*
Placenta / metabolism*,  pathology
Placental Circulation
Pregnancy
Pregnancy Complications / diagnosis,  genetics*,  metabolism
RNA Interference*
Chemical
Reg. No./Substance:
0/MicroRNAs

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