Document Detail


MicroRNAs in platelet physiology and pathology.
MedLine Citation:
PMID:  23392306     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MicroRNAs (miRNAs), highly conserved, short (approx. 22 nucleotides) non-coding RNAs, exhibit a fine-tune control over gene expression by complementary sequence binding and translational repression of protein coding mRNA transcripts. Recently, the role of miRNAs has been increasingly investigated in various physiological or pathophysiological events.Circulating platelets are crucial for coagulation physiology to maintain haemostatic balance and are involved in various pathologies such as atherosclerosis and thrombosis. Anucleate platelets lack genomic DNA but inherit diverse array of functional coding or non-coding RNAs and translational machinery from their parent cells - megakaryocytes enabling activated platelets to synthesize proteins which suggests the possibility of post transcriptional gene regulation in platelets. Expression of functionally active miRNAs in platelets changes during platelet activation indicating a role in platelet biology.Here, we present a review on recently identified platelet miRNAs and their role in platelet physiology that is essential for maintaining haemostasis.MicroRNAs.
Authors:
S Dangwal; T Thum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hämostaseologie     Volume:  33     ISSN:  0720-9355     ISO Abbreviation:  Hamostaseologie     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8204531     Medline TA:  Hamostaseologie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  IM    
Affiliation:
Thomas Thum, MD, PhD, Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany, Tel. +49/(0)511/532 52 73, Fax +49/(0)511/532 52 74, E-Mail: thum.thomas@mh-hannover.de.
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