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MicroRNAs in neural cell development and brain diseases.
MedLine Citation:
PMID:  22227902     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MicroRNAs play important roles in post-transcriptional regulation of gene expression by inhibiting protein translation and/or promoting mRNA degradation. Importantly, biogenesis of microRNAs displays specific temporal and spatial profiles in distinct cell and tissue types and hence affects a broad spectrum of biological functions in normal cell growth and tumor development. Recent discoveries have revealed sophisticated mechanisms that control microRNA production and homeostasis in response to developmental and extracellular signals. Moreover, a link between dysregulation of microRNAs and human brain disorders has become increasingly evident. In this review, we focus on recent advances in understanding the regulation of microRNA biogenesis and function in neuronal and glial development in the mammalian brain, and dysregulation of the microRNA pathway in neurodevelopmental and neurodegenerative diseases.
Authors:
Wei Feng; Yue Feng
Publication Detail:
Type:  Journal Article     Date:  2012-01-07
Journal Detail:
Title:  Science China. Life sciences     Volume:  54     ISSN:  1869-1889     ISO Abbreviation:  Sci China Life Sci     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-01-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101529880     Medline TA:  Sci China Life Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  1103-12     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA, 30322, USA.
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