| MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment. | |
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MedLine Citation:
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PMID: 23281405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The management of cardiovascular risk through lifestyle modification and pharmacotherapy is paramount to the prevention of cardiovascular disease. Epidemiological studies have identified obesity, dyslipidemia, diabetes, and hypertension as interrelated factors that negatively affect cardiovascular health. Recently, genetic and pharmacological evidence in model systems has implicated microRNAs as dynamic modifiers of disease pathogenesis. An expanded understanding of the function of microRNAs in gene regulatory networks associated with cardiovascular risk will enable identification of novel genetic mechanisms of disease and inform the development of innovative therapeutic strategies. |
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Authors:
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Daniel Quiat; Eric N Olson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2013-01-02 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 123 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: 2013-03-11 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 11-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular Diseases / epidemiology, etiology, genetics*, metabolism*, therapy* Diabetes Complications / epidemiology, genetics, metabolism, therapy Dyslipidemias / complications, epidemiology, genetics, metabolism, therapy Humans MicroRNAs / genetics*, metabolism* Obesity / complications, epidemiology, genetics, metabolism, therapy Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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1F30HL103013/HL/NHLBI NIH HHS; F30 HL103013/HL/NHLBI NIH HHS; R01 HL077439/HL/NHLBI NIH HHS; R01 HL093039/HL/NHLBI NIH HHS; R01 HL111665/HL/NHLBI NIH HHS; U01 HL100401/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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