Document Detail


MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment.
MedLine Citation:
PMID:  23281405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The management of cardiovascular risk through lifestyle modification and pharmacotherapy is paramount to the prevention of cardiovascular disease. Epidemiological studies have identified obesity, dyslipidemia, diabetes, and hypertension as interrelated factors that negatively affect cardiovascular health. Recently, genetic and pharmacological evidence in model systems has implicated microRNAs as dynamic modifiers of disease pathogenesis. An expanded understanding of the function of microRNAs in gene regulatory networks associated with cardiovascular risk will enable identification of novel genetic mechanisms of disease and inform the development of innovative therapeutic strategies.
Authors:
Daniel Quiat; Eric N Olson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-02
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-03-11     Revised Date:  2014-04-23    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiovascular Diseases / epidemiology,  etiology,  genetics*,  metabolism*,  therapy*
Diabetes Complications / epidemiology,  genetics,  metabolism,  therapy
Dyslipidemias / complications,  epidemiology,  genetics,  metabolism,  therapy
Humans
MicroRNAs / genetics*,  metabolism*
Obesity / complications,  epidemiology,  genetics,  metabolism,  therapy
Risk Factors
Grant Support
ID/Acronym/Agency:
1F30HL103013/HL/NHLBI NIH HHS; F30 HL103013/HL/NHLBI NIH HHS; R01 DK099653/DK/NIDDK NIH HHS; R01 HL077439/HL/NHLBI NIH HHS; R01 HL093039/HL/NHLBI NIH HHS; R01 HL111665/HL/NHLBI NIH HHS; U01 HL100401/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs
Comments/Corrections

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