Document Detail


MicroRNAs in androgen-dependent PCa.
MedLine Citation:
PMID:  23276959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prostate cancer (PCa) is the most commonly diagnosed cancer among men in Western countries and is one of the leading causes of cancer deaths. The growth and progression of PCa is related to androgen levels. In cancer, nicroRNAs (miRs) function as either oncogenes or tumor suppressor genes. In androgen-dependent PCa, miRs play a role in the growth, development, progression, and metastasis of the disease, and are also involved in the response to therapy and therefore affect the prognosis. In this review, we focus on the role played by miRs concerning the mechanisms of androgen-dependent PCa.
Authors:
Kai-Chang Zhu; Jia-ju Lu; Xiao-Lin Xu; Jian-mei Sun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  748-55     Citation Subset:  IM    
Affiliation:
Department of Neonatology, Fengxian Branch of Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 201499, China.
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MeSH Terms
Descriptor/Qualifier:
Androgens / physiology*
Disease Progression
Humans
Male
MicroRNAs / genetics*,  physiology,  therapeutic use
Neoplasm Metastasis / genetics
Neoplasms, Hormone-Dependent / genetics*,  pathology,  physiopathology
Prostatic Neoplasms / genetics*,  pathology
Receptors, Androgen / genetics,  physiology
Chemical
Reg. No./Substance:
0/Androgens; 0/MIRN125 microRNA, human; 0/MIRN141 microRNA, human; 0/MIRN205 microRNA, human; 0/MIRN21 microRNA, human; 0/MicroRNAs; 0/Receptors, Androgen; 0/mirnlet7 microRNA, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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