| MicroRNAs in stress signaling and human disease. | |
| | |
MedLine Citation:
|
PMID: 22424228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics. |
| | |
Authors:
|
Joshua T Mendell; Eric N Olson |
Related Documents
:
|
17979028 - Biologicals in the treatment of psoriasis. 3960798 - Psoriasis. how to keep mild disease from becoming severe. 11381858 - Evaluation of pigmented lesions of the nail unit. 15663338 - Role of antifungal agents in the treatment of seborrheic dermatitis. 21036078 - Advances in the understanding of pathogenesis, and diagnostics and therapeutics for fel... 9205988 - Carcinoid heart disease with severe hypoxia due to interatrial shunt through patent for... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Cell Volume: 148 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-03-19 Completed Date: 2012-05-04 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
|
Languages: eng Pagination: 1172-87 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390-9148, USA. joshua.mendell@utsouthwestern.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Disease / genetics* Humans MicroRNAs / genetics*, metabolism* Signal Transduction* |
| Grant Support | |
ID/Acronym/Agency:
|
P01 CA134292-03/CA/NCI NIH HHS; P01CA134292/CA/NCI NIH HHS; R01 CA120185-05/CA/NCI NIH HHS; R01 HL077439/HL/NHLBI NIH HHS; R01 HL077439-08/HL/NHLBI NIH HHS; R01 HL093039/HL/NHLBI NIH HHS; R01 HL093039-04/HL/NHLBI NIH HHS; R01 HL111665/HL/NHLBI NIH HHS; R01CA120185/CA/NCI NIH HHS; R01HL093039/HL/NHLBI NIH HHS; R01HL77439/HL/NHLBI NIH HHS; U01 HL100401/HL/NHLBI NIH HHS; U01 HL100401-04/HL/NHLBI NIH HHS; U01HL100401/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/MicroRNAs |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diabetes Mellitus and the ? Cell: The Last Ten Years.
Next Document: The amyloid state of proteins in human diseases.