Document Detail


MicroRNAs in Myocardial Infarction.
MedLine Citation:
PMID:  23325477     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The complexity of posttranscriptional regulation by noncoding microRNAs (miRNAs, miRs) is still not completely understood. A large fraction of the genome is under the control of miRs via (partial) complementary base pairing within the corresponding mRNA region. Myocardial infarction is characterized by strongly altered gene expression, deregulation of underlying signaling pathways, and crucial participation of several miRs in this context. Mechanistically, miR induction or repression after myocardial infarction triggers downstream events in a cell-type-specific manner, and interference with endogenous miR expression might regulate overall cardiac function. In this brief review, we (1) summarize the current knowledge about the importance of several miRs after myocardial infarction, (2) report about novel miR-based therapeutic approaches to counteract maladaptive remodeling upon cardiac ischemia, and (3) discuss briefly the use of miRs as biomarkers for cardiac ischemia.
Authors:
Jan Fiedler; Thomas Thum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  33     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-5     Citation Subset:  IM    
Affiliation:
or Thomas Thum, PhD, Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. : fiedler.jan@mh-hannover.de or thum.thomas@mh-hannover.de.
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